Ndr_family
Relationship
Comment
RTP/Drg1/Ndr1 genes are repressed by the proto-oncogenes N-myc and c-myc. Members of this family are found in wide variety of multicellular eukaryotes, including plants (ndr nothing to do with nodal-related genes) Ndr1 included in alpha/beta hydolase PF00561 now have a Pfam family PF03096. Shaw et al Proteins 2002 May 1;47(2):163-8 identified this family as alpha/beta hydrolase. Kalaydjieva et al. showed that human-NDRG1 is mutated in hereditary motor and sensory neuropathy-Lom. Bhaduri et al. showed that ratno-ndr4 (Bdm1) is associated with hot water epilepsy. Mitchelmore et al. showed that NDRG2 is upregulated in Alzheimer's disease. NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase as published by Dong et al. (obsolete subfamilies IPR030693 Protein NDRG1; IPR030690 Protein NDRG2; IPR030692 Protein NDRG3; IPR030695 Protein NDRG4)Database
Interpro : IPR004142 NDRG
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF03096 Ndr
Prints : No Print
EC Number : No EC Number
References (14)
| Title : A review on the role of NDRG1 in different cancers - Ghafouri-Fard_2023_Mol.Biol.Rep__ |
| Author(s) : Ghafouri-Fard S , Ahmadi Teshnizi S , Hussen BM , Taheri M , Sharifi G |
| Ref : Mol Biol Rep , : , 2023 |
| Abstract : Ghafouri-Fard_2023_Mol.Biol.Rep__ |
| ESTHER : Ghafouri-Fard_2023_Mol.Biol.Rep__ |
| PubMedSearch : Ghafouri-Fard_2023_Mol.Biol.Rep__ |
| PubMedID: 37249826 |
| Gene_locus related to this paper: human-NDRG1 |
| Title : Prognostic and biological role of the N-Myc downstream-regulated gene family in hepatocellular carcinoma - Yin_2022_World.J.Clin.Cases_10_2072 |
| Author(s) : Yin X , Yu H , He XK , Yan SX |
| Ref : World J Clin Cases , 10 :2072 , 2022 |
| Abstract : Yin_2022_World.J.Clin.Cases_10_2072 |
| ESTHER : Yin_2022_World.J.Clin.Cases_10_2072 |
| PubMedSearch : Yin_2022_World.J.Clin.Cases_10_2072 |
| PubMedID: 35321174 |
| Title : NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase - Dong_2021_PLoS.Pathog_17_e1009645 |
| Author(s) : Dong L , Dong J , Xiang M , Lei P , Li Z , Zhang F , Sun X , Niu D , Bai L , Lan K |
| Ref : PLoS Pathog , 17 :e1009645 , 2021 |
| Abstract : Dong_2021_PLoS.Pathog_17_e1009645 |
| ESTHER : Dong_2021_PLoS.Pathog_17_e1009645 |
| PubMedSearch : Dong_2021_PLoS.Pathog_17_e1009645 |
| PubMedID: 34077484 |
| Gene_locus related to this paper: human-NDRG1 |
| Title : Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family - Le_2021_FASEB.J_35_e21961 |
| Author(s) : Le N , Hufford TM , Park JS , Brewster RM |
| Ref : FASEB Journal , 35 :e21961 , 2021 |
| Abstract : Le_2021_FASEB.J_35_e21961 |
| ESTHER : Le_2021_FASEB.J_35_e21961 |
| PubMedSearch : Le_2021_FASEB.J_35_e21961 |
| PubMedID: 34665878 |
| Title : Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D - Skedsmo_2021_Neuromuscul.Disord_31_56 |
| Author(s) : Skedsmo FS , Espenes A , Tranulis MA , Matiasek K , Gunnes G , Bjerkas I , Moe L , Roed SS , Berendt M , Fredholm M , Rohdin C , Shelton GD , Bruheim P , Stafsnes MH , Bartosova Z , Hermansen LC , Stigen , Jaderlund KH |
| Ref : Neuromuscular Disorders , 31 :56 , 2021 |
| Abstract : Skedsmo_2021_Neuromuscul.Disord_31_56 |
| ESTHER : Skedsmo_2021_Neuromuscul.Disord_31_56 |
| PubMedSearch : Skedsmo_2021_Neuromuscul.Disord_31_56 |
| PubMedID: 33334662 |
| Title : The Role of N-myc Downstream-Regulated Gene Family in Glioma Based on Bioinformatics Analysis - Tang_2021_DNA.Cell.Biol_40_949 |
| Author(s) : Tang T , Wang H , Han Y , Huang H , Niu W , Fei M , Zhu Y |
| Ref : DNA & Cell Biology , 40 :949 , 2021 |
| Abstract : Tang_2021_DNA.Cell.Biol_40_949 |
| ESTHER : Tang_2021_DNA.Cell.Biol_40_949 |
| PubMedSearch : Tang_2021_DNA.Cell.Biol_40_949 |
| PubMedID: 34115542 |
| Title : The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways. - Kovacevic_2013_Antioxid.Redox.Signal_18_874 |
| Author(s) : Kovacevic Z , Chikhani S , Lui GY , Sivagurunathan S , Richardson DR |
| Ref : Antioxid Redox Signal , 18 :874 , 2013 |
| Abstract : Kovacevic_2013_Antioxid.Redox.Signal_18_874 |
| ESTHER : Kovacevic_2013_Antioxid.Redox.Signal_18_874 |
| PubMedSearch : Kovacevic_2013_Antioxid.Redox.Signal_18_874 |
| PubMedID: 22462691 |
| Title : NDRG2 and PRA1 interact and synergistically inhibit T-cell factor\/beta-catenin signaling. - Kim_2012_FEBS.Lett_586_3962 |
| Author(s) : Kim JT , Kim JW , Kang YH , Kim KD , Lee SJ , Choi SC , Kim KS , Chae SK , Lim JS , Lee HG |
| Ref : FEBS Letters , 586 :3962 , 2012 |
| Abstract : Kim_2012_FEBS.Lett_586_3962 |
| ESTHER : Kim_2012_FEBS.Lett_586_3962 |
| PubMedSearch : Kim_2012_FEBS.Lett_586_3962 |
| PubMedID: 23068607 |
| Title : Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor - Hwang_2011_J.Biol.Chem_286_12450 |
| Author(s) : Hwang J , Kim Y , Kang HB , Jaroszewski L , Deacon AM , Lee H , Choi WC , Kim KJ , Kim CH , Kang BS , Lee JO , Oh TK , Kim JW , Wilson IA , Kim MH |
| Ref : Journal of Biological Chemistry , 286 :12450 , 2011 |
| Abstract : Hwang_2011_J.Biol.Chem_286_12450 |
| ESTHER : Hwang_2011_J.Biol.Chem_286_12450 |
| PubMedSearch : Hwang_2011_J.Biol.Chem_286_12450 |
| PubMedID: 21247902 |
| Gene_locus related to this paper: human-NDRG2 |
| Title : The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications - Melotte_2010_FASEB.J_24_4153 |
| Author(s) : Melotte V , Qu X , Ongenaert M , Van Criekinge W , de Bruine AP , Baldwin HS , van Engeland M |
| Ref : FASEB Journal , 24 :4153 , 2010 |
| Abstract : Melotte_2010_FASEB.J_24_4153 |
| ESTHER : Melotte_2010_FASEB.J_24_4153 |
| PubMedSearch : Melotte_2010_FASEB.J_24_4153 |
| PubMedID: 20667976 |
| Title : NDRG2: a novel Alzheimer's disease associated protein - Mitchelmore_2004_Neurobiol.Dis_16_48 |
| Author(s) : Mitchelmore C , Buchmann-Moller S , Rask L , West MJ , Troncoso JC , Jensen NA |
| Ref : Neurobiol Dis , 16 :48 , 2004 |
| Abstract : Mitchelmore_2004_Neurobiol.Dis_16_48 |
| ESTHER : Mitchelmore_2004_Neurobiol.Dis_16_48 |
| PubMedSearch : Mitchelmore_2004_Neurobiol.Dis_16_48 |
| PubMedID: 15207261 |
| Gene_locus related to this paper: human-NDRG2 |
| Title : Fold prediction and comparative modeling of Bdm1: a probable alpha\/beta hydrolase associated with hot water epilepsy - Bhaduri_2003_J.Mol.Model_9_3 |
| Author(s) : Bhaduri A , Krishnaswamy L , Ullal GR , Panicker MM , Sowdhamini R |
| Ref : J Mol Model , 9 :3 , 2003 |
| Abstract : Bhaduri_2003_J.Mol.Model_9_3 |
| ESTHER : Bhaduri_2003_J.Mol.Model_9_3 |
| PubMedSearch : Bhaduri_2003_J.Mol.Model_9_3 |
| PubMedID: 12638006 |
| Gene_locus related to this paper: ratno-ndr4 |
| Title : Identification of a novel class in the alpha\/beta hydrolase fold superfamily: the N-myc differentiation-related proteins - Shaw_2002_Proteins_47_163 |
| Author(s) : Shaw E , McCue LA , Lawrence CE , Dordick JS |
| Ref : Proteins , 47 :163 , 2002 |
| Abstract : Shaw_2002_Proteins_47_163 |
| ESTHER : Shaw_2002_Proteins_47_163 |
| PubMedSearch : Shaw_2002_Proteins_47_163 |
| PubMedID: 11933063 |
| Title : N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom - Kalaydjieva_2000_Am.J.Hum.Genet_67_47 |
| Author(s) : Kalaydjieva L , Gresham D , Gooding R , Heather L , Baas F , de Jonge R , Blechschmidt K , Angelicheva D , Chandler D , Worsley P , Rosenthal A , King RH , Thomas PK |
| Ref : American Journal of Human Genetics , 67 :47 , 2000 |
| Abstract : Kalaydjieva_2000_Am.J.Hum.Genet_67_47 |
| ESTHER : Kalaydjieva_2000_Am.J.Hum.Genet_67_47 |
| PubMedSearch : Kalaydjieva_2000_Am.J.Hum.Genet_67_47 |
| PubMedID: 10831399 |
| Gene_locus related to this paper: human-NDRG1 |
Structures (8)
Genes Proteins in Ndr_family family (258)
Fragments of genes in Ndr_family family (57)
Structures in Ndr_family family (8)No substrate
No Inhibitor