MpaH

Relationship

Family: MpaH

Block: X

Parent Family: No family

Comment

Penicillium brevicompactum MpaH Hydrolase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Farnesyl-5,7-dihydroxy-4,6-dimethylphthalide(DHDMP) substrate of mpaH for transformation into demethylmycophenolic acid (DMMPA). The family is extracted from 6_AlphaBeta_hydrolase.

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in	Fasta
Nucleotide in	Fasta
Alignment with Multalin	Text only
Seed alignment with MAFFT	No colour
Alignment with MAFFT	No colour
Dendrogram	The dnd file

References (1)

Title : Compartmentalized biosynthesis of mycophenolic acid - Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305

Author(s) : Zhang W , Du L , Qu Z , Zhang X , Li F , Li Z , Qi F , Wang X , Jiang Y , Men P , Sun J , Cao S , Geng C , Wan X , Liu C , Li S

Ref : Proc Natl Acad Sci U S A , 116 :13305 , 2019

Abstract : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305

ESTHER : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305

PubMedSearch : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305

PubMedID: 31209052

Gene_locus related to this paper: penbr-mpaH , penbr-mpac

Structures (2)

Genes Proteins in MpaH family (201)

Fragments of genes in MpaH family (14)

Structures in MpaH family (2)

Substrates in MpaH family (2)

Inhibitors in MpaH family (1)