Interpro : IPR023594 Haloalkane dehalogenase, subfamily 2
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00561 Abhydrolase_1
Prints : No Print
EC Number : 3.8.1.5
Title : Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts - Chaloupkova_2019_ACS.Catal_9_48103 |
Author(s) : Chaloupkova, R , Liskova V , Tool M , Markova K , Sebestova E , Hernychova L , Marek M , Pinto GP , Pluskal D , Waterman J , Prokop Z , Damborsky J |
Ref : ACS Catal , 9 :4810 , 2019 |
Abstract : Chaloupkova_2019_ACS.Catal_9_48103 |
ESTHER : Chaloupkova_2019_ACS.Catal_9_48103 |
PubMedSearch : Chaloupkova_2019_ACS.Catal_9_48103 |
PubMedID: |
Gene_locus related to this paper: 9zzzz-AncHLDRLuc2 , 9zzzz-AncHLDRLuc , renre-luc |
Title : A Haloalkane Dehalogenase from a Marine Microbial Consortium Possessing Exceptionally Broad Substrate Specificity - Buryska_2018_Appl.Environ.Microbiol_84_ |
Author(s) : Buryska T , Babkova P , Vavra O , Damborsky J , Prokop Z |
Ref : Applied Environmental Microbiology , 84 : , 2018 |
Abstract : Buryska_2018_Appl.Environ.Microbiol_84_ |
ESTHER : Buryska_2018_Appl.Environ.Microbiol_84_ |
PubMedSearch : Buryska_2018_Appl.Environ.Microbiol_84_ |
PubMedID: 29101190 |
Gene_locus related to this paper: 9cyan-q6dnd9 |
Title : A puzzling homology: a brittle star using a putative cnidarian-type luciferase for bioluminescence - Delroisse_2017_Open.Biol_7_ |
Author(s) : Delroisse J , Ullrich-Luter E , Blaue S , Ortega-Martinez O , Eeckhaut I , Flammang P , Mallefet J |
Ref : Open Biol , 7 : , 2017 |
Abstract : Delroisse_2017_Open.Biol_7_ |
ESTHER : Delroisse_2017_Open.Biol_7_ |
PubMedSearch : Delroisse_2017_Open.Biol_7_ |
PubMedID: 28381628 |
Title : Engineering a de novo transport tunnel - Brezovsky_2016_ACS.Catal_6_7597 |
Author(s) : Brezovsky J , Babkova P , Degtjarik O , Fortova A , Gora A , Iermak I , Rezacova P , Dvorak P , Kuta-Smatanova I , Prokop Z , Chaloupkova R , Damborsky J |
Ref : ACS Catal , 6 :7597 , 2016 |
Abstract : Brezovsky_2016_ACS.Catal_6_7597 |
ESTHER : Brezovsky_2016_ACS.Catal_6_7597 |
PubMedSearch : Brezovsky_2016_ACS.Catal_6_7597 |
PubMedID: |
Gene_locus related to this paper: sphpi-linb |
Title : Balancing the stability-activity trade-off by fine-tuning dehalogenase access tunnels - Liskova_2015_ChemCatChem_7_648 |
Author(s) : Liskova V , Bednar D , Prudnikova T , Rezacova P , Koudelakova T , Sebestova E , Kuta-Smatanova I , Brezovsky J , Chaloupkova R , Damborsky J |
Ref : ChemCatChem , 7 :648 , 2015 |
Abstract : Liskova_2015_ChemCatChem_7_648 |
ESTHER : Liskova_2015_ChemCatChem_7_648 |
PubMedSearch : Liskova_2015_ChemCatChem_7_648 |
PubMedID: |
Gene_locus related to this paper: rhoso-halo1 |
Title : Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae - Novak_2014_FEBS.Lett_588_1616 |
Author(s) : Novak HR , Sayer C , Isupov MN , Gotz D , Spragg AM , Littlechild JA |
Ref : FEBS Letters , 588 :1616 , 2014 |
Abstract : Novak_2014_FEBS.Lett_588_1616 |
ESTHER : Novak_2014_FEBS.Lett_588_1616 |
PubMedSearch : Novak_2014_FEBS.Lett_588_1616 |
PubMedID: 24613925 |
Gene_locus related to this paper: 9rhob-KF032932 |
Title : Dynamics and hydration explain failed functional transformation in dehalogenase design - Sykora_2014_Nat.Chem.Biol_10_428 |
Author(s) : Sykora J , Brezovsky J , Koudelakova T , Lahoda M , Fortova A , Chernovets T , Chaloupkova R , Stepankova V , Prokop Z , Smatanova IK , Hof M , Damborsky J |
Ref : Nat Chemical Biology , 10 :428 , 2014 |
Abstract : Sykora_2014_Nat.Chem.Biol_10_428 |
ESTHER : Sykora_2014_Nat.Chem.Biol_10_428 |
PubMedSearch : Sykora_2014_Nat.Chem.Biol_10_428 |
PubMedID: 24727901 |
Gene_locus related to this paper: rhoso-halo1 |
Title : Crystal structure of the novel haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58 reveals a special halide-stabilizing pair and enantioselectivity mechanism - Guan_2014_Appl.Microbiol.Biotechnol_98_8573 |
Author(s) : Guan L , Yabuki H , Okai M , Ohtsuka J , Tanokura M |
Ref : Applied Microbiology & Biotechnology , 98 :8573 , 2014 |
Abstract : Guan_2014_Appl.Microbiol.Biotechnol_98_8573 |
ESTHER : Guan_2014_Appl.Microbiol.Biotechnol_98_8573 |
PubMedSearch : Guan_2014_Appl.Microbiol.Biotechnol_98_8573 |
PubMedID: 24770384 |
Gene_locus related to this paper: agrtu-DHAA |
Title : Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel - Koudelakova_2013_Angew.Chem.Int.Ed.Engl_52_1959 |
Author(s) : Koudelakova T , Chaloupkova R , Brezovsky J , Prokop Z , Sebestova E , Hesseler M , Khabiri M , Plevaka M , Kulik D , Kuta Smatanova I , Rezacova P , Ettrich R , Bornscheuer UT , Damborsky J |
Ref : Angew Chem Int Ed Engl , 52 :1959 , 2013 |
Abstract : Koudelakova_2013_Angew.Chem.Int.Ed.Engl_52_1959 |
ESTHER : Koudelakova_2013_Angew.Chem.Int.Ed.Engl_52_1959 |
PubMedSearch : Koudelakova_2013_Angew.Chem.Int.Ed.Engl_52_1959 |
PubMedID: 23303607 |
Gene_locus related to this paper: rhoso-halo1 |
Title : Expansion of access tunnels and active-site cavities influence activity of haloalkane dehalogenases in organic cosolvents - Stepankova_2013_Chembiochem_14_890 |
Author(s) : Stepankova V , Khabiri M , Brezovsky J , Pavelka A , Sykora J , Amaro M , Minofar B , Prokop Z , Hof M , Ettrich R , Chaloupkova R , Damborsky J |
Ref : Chembiochem , 14 :890 , 2013 |
Abstract : Stepankova_2013_Chembiochem_14_890 |
ESTHER : Stepankova_2013_Chembiochem_14_890 |
PubMedSearch : Stepankova_2013_Chembiochem_14_890 |
PubMedID: 23564727 |
Gene_locus related to this paper: rhoso-halo1 |
Title : Crystal Structure and Site-Directed Mutagenesis Analyses of Haloalkane Dehalogenase LinB from Sphingobium sp. Strain MI1205 - Okai_2013_J.Bacteriol_195_2642 |
Author(s) : Okai M , Ohtsuka J , Imai LF , Mase T , Moriuchi R , Tsuda M , Nagata K , Nagata Y , Tanokura M |
Ref : Journal of Bacteriology , 195 :2642 , 2013 |
Abstract : Okai_2013_J.Bacteriol_195_2642 |
ESTHER : Okai_2013_J.Bacteriol_195_2642 |
PubMedSearch : Okai_2013_J.Bacteriol_195_2642 |
PubMedID: 23564170 |
Gene_locus related to this paper: sphpi-q6vqx3 |
Title : Structure and activity of DmmA, a marine haloalkane dehalogenase - Gehret_2012_Protein.Sci_21_239 |
Author(s) : Gehret JJ , Gu L , Geders TW , Brown WC , Gerwick L , Gerwick WH , Sherman DH , Smith JL |
Ref : Protein Science , 21 :239 , 2012 |
Abstract : Gehret_2012_Protein.Sci_21_239 |
ESTHER : Gehret_2012_Protein.Sci_21_239 |
PubMedSearch : Gehret_2012_Protein.Sci_21_239 |
PubMedID: 22124946 |
Gene_locus related to this paper: 9cyan-q6dnd9 |
Title : Substrate specificity of haloalkane dehalogenases - Koudelakova_2011_Biochem.J_435_345 |
Author(s) : Koudelakova T , Chovancova E , Brezovsky J , Monincova M , Fortova A , Jarkovsky J , Damborsky J |
Ref : Biochemical Journal , 435 :345 , 2011 |
Abstract : Koudelakova_2011_Biochem.J_435_345 |
ESTHER : Koudelakova_2011_Biochem.J_435_345 |
PubMedSearch : Koudelakova_2011_Biochem.J_435_345 |
PubMedID: 21294712 |
Gene_locus related to this paper: agrtu-DHAA , brael-e2rv62 , braja-dhaa , myctu-linb , myctu-Rv1833c , rhoba-DHLA , rhoso-halo1 , sphpi-linb , xanau-halo1 |
Title : Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering - |
Author(s) : Prokop Z , Sato Y , Brezovsky J , Mozga T , Chaloupkova R , Koudelakova T , Jerabek P , Stepankova V , Natsume R , van Leeuwen JG , Janssen DB , Florian J , Nagata Y , Senda T , Damborsky J |
Ref : Angew Chem Int Ed Engl , 49 :6111 , 2010 |
PubMedID: 20645368 |
Gene_locus related to this paper: braja-dhaa |
Title : Pathways and mechanisms for product release in the engineered haloalkane dehalogenases explored using classical and random acceleration molecular dynamics simulations - Klvana_2009_J.Mol.Biol_392_1339 |
Author(s) : Klvana M , Pavlova M , Koudelakova T , Chaloupkova R , Dvorak P , Prokop Z , Stsiapanava A , Kuty M , Kuta-Smatanova I , Dohnalek J , Kulhanek P , Wade RC , Damborsky J |
Ref : Journal of Molecular Biology , 392 :1339 , 2009 |
Abstract : Klvana_2009_J.Mol.Biol_392_1339 |
ESTHER : Klvana_2009_J.Mol.Biol_392_1339 |
PubMedSearch : Klvana_2009_J.Mol.Biol_392_1339 |
PubMedID: 19577578 |
Gene_locus related to this paper: rhoso-halo1 |
Title : X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579 - Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
Author(s) : Mazumdar PA , Hulecki JC , Cherney MM , Garen CR , James MN |
Ref : Biochimica & Biophysica Acta , 1784 :351 , 2008 |
Abstract : Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
ESTHER : Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
PubMedSearch : Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
PubMedID: 18062934 |
Gene_locus related to this paper: myctu-linb |
Title : Phylogenetic analysis of haloalkane dehalogenases - Chovancova_2007_Proteins_67_305 |
Author(s) : Chovancova E , Kosinski J , Bujnicki JM , Damborsky J |
Ref : Proteins , 67 :305 , 2007 |
Abstract : Chovancova_2007_Proteins_67_305 |
ESTHER : Chovancova_2007_Proteins_67_305 |
PubMedSearch : Chovancova_2007_Proteins_67_305 |
PubMedID: 17295320 |
Title : Crystal structures of the luciferase and green fluorescent protein from Renilla reniformis - Loening_2007_J.Mol.Biol_374_1017 |
Author(s) : Loening AM , Fenn TD , Gambhir SS |
Ref : Journal of Molecular Biology , 374 :1017 , 2007 |
Abstract : Loening_2007_J.Mol.Biol_374_1017 |
ESTHER : Loening_2007_J.Mol.Biol_374_1017 |
PubMedSearch : Loening_2007_J.Mol.Biol_374_1017 |
PubMedID: 17980388 |
Gene_locus related to this paper: renre-luc |
Title : Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-Ray crystallography and microcalorimetry - Monincova_2007_Appl.Environ.Microbiol_73_2005 |
Author(s) : Monincova M , Prokop Z , Vevodova J , Nagata Y , Damborsky J |
Ref : Applied Environmental Microbiology , 73 :2005 , 2007 |
Abstract : Monincova_2007_Appl.Environ.Microbiol_73_2005 |
ESTHER : Monincova_2007_Appl.Environ.Microbiol_73_2005 |
PubMedSearch : Monincova_2007_Appl.Environ.Microbiol_73_2005 |
PubMedID: 17259360 |
Gene_locus related to this paper: sphpi-linb |
Title : Crystal structure of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 A resolution: dynamics of catalytic residues - Oakley_2004_Biochemistry_43_870 |
Author(s) : Oakley AJ , Klvana M , Otyepka M , Nagata Y , Wilce MC , Damborsky J |
Ref : Biochemistry , 43 :870 , 2004 |
Abstract : Oakley_2004_Biochemistry_43_870 |
ESTHER : Oakley_2004_Biochemistry_43_870 |
PubMedSearch : Oakley_2004_Biochemistry_43_870 |
PubMedID: 14744129 |
Gene_locus related to this paper: sphpi-linb |
Title : Evolving haloalkane dehalogenases - Janssen_2004_Curr.Opin.Chem.Biol_8_150 |
Author(s) : Janssen DB |
Ref : Curr Opin Chemical Biology , 8 :150 , 2004 |
Abstract : Janssen_2004_Curr.Opin.Chem.Biol_8_150 |
ESTHER : Janssen_2004_Curr.Opin.Chem.Biol_8_150 |
PubMedSearch : Janssen_2004_Curr.Opin.Chem.Biol_8_150 |
PubMedID: 15062775 |
Title : Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates - Streltsov_2003_Biochemistry_42_10104 |
Author(s) : Streltsov VA , Prokop Z , Damborsky J , Nagata Y , Oakley A , Wilce MC |
Ref : Biochemistry , 42 :10104 , 2003 |
Abstract : Streltsov_2003_Biochemistry_42_10104 |
ESTHER : Streltsov_2003_Biochemistry_42_10104 |
PubMedSearch : Streltsov_2003_Biochemistry_42_10104 |
PubMedID: 12939138 |
Gene_locus related to this paper: sphpi-linb |
Title : Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition - Oakley_2002_Biochemistry_41_4847 |
Author(s) : Oakley AJ , Prokop Z , Bohac M , Kmunicek J , Jedlicka T , Monincova M , Kuta-Smatanova I , Nagata Y , Damborsky J , Wilce MC |
Ref : Biochemistry , 41 :4847 , 2002 |
Abstract : Oakley_2002_Biochemistry_41_4847 |
ESTHER : Oakley_2002_Biochemistry_41_4847 |
PubMedSearch : Oakley_2002_Biochemistry_41_4847 |
PubMedID: 11939779 |
Gene_locus related to this paper: sphpi-linb |
Title : Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 - Marek_2000_Biochemistry_39_14082 |
Author(s) : Marek J , Vevodova J , Smatanova IK , Nagata Y , Svensson LA , Newman J , Takagi M , Damborsky J |
Ref : Biochemistry , 39 :14082 , 2000 |
Abstract : Marek_2000_Biochemistry_39_14082 |
ESTHER : Marek_2000_Biochemistry_39_14082 |
PubMedSearch : Marek_2000_Biochemistry_39_14082 |
PubMedID: 11087355 |
Gene_locus related to this paper: sphpi-linb |
Title : Haloalkane dehalogenases: structure of a Rhodococcus enzyme - Newman_1999_Biochemistry_38_16105 |
Author(s) : Newman J , Peat TS , Richard R , Kan L , Swanson PE , Affholter JA , Holmes IH , Schindler JF , Unkefer CJ , Terwilliger TC |
Ref : Biochemistry , 38 :16105 , 1999 |
Abstract : Newman_1999_Biochemistry_38_16105 |
ESTHER : Newman_1999_Biochemistry_38_16105 |
PubMedSearch : Newman_1999_Biochemistry_38_16105 |
PubMedID: 10587433 |
Gene_locus related to this paper: rhoso-halo1 |
Title : Repositioning the catalytic triad aspartic acid of haloalkane dehalogenase: effects on stability, kinetics, and structure - Krooshof_1997_Biochemistry_36_9571 |
Author(s) : Krooshof GH , Kwant EM , Damborsky J , Koca J , Janssen DB |
Ref : Biochemistry , 36 :9571 , 1997 |
Abstract : Krooshof_1997_Biochemistry_36_9571 |
ESTHER : Krooshof_1997_Biochemistry_36_9571 |
PubMedSearch : Krooshof_1997_Biochemistry_36_9571 |
PubMedID: 9236003 |
Structures (131)
Genes Proteins in Haloalkane_dehalogenase-HLD2 family (72)
No fragment of genes
Structures in Haloalkane_dehalogenase-HLD2 family (131)Substrates in Haloalkane_dehalogenase-HLD2 family (35)
Inhibitors in Haloalkane_dehalogenase-HLD2 family (30)