Fungal_carboxylesterase_lipase
Relationship
Comment
This family was extracted from the previous Carboxylesterase COesterase family. Carboxylesterase, type B (COesterase) is very successful in fungi. Grouped with Lipase_3 in Family Fungal lipases in scop database. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10) LED_Database abH03 abH02. The presence of a water/lipid interface dramatically enhances the hydrolytic activity of lipases. The activation is associated with a conformational change. The Ser-His-Asp/Glu catalytic triad is occluded by a polypeptide flap (lid) and is not exposed to the solvent until the lid is open. A protein of this family lacking the catalytic serine is a dirigent protein which controls the stereoselectivity of multicopper oxidase(VdtB)-catalyzed phenol coupling in viriditoxin biosynthesis (Hu et al. 2019)Database
Interpro : IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : PDOC00112
Pfam : PF00135 COesterase
Prints : No Print
EC Number : 3.1.1.3
References (14)
| Title : A Global Survey of Carbohydrate Esterase Families 1 and 10 in Oomycetes - de Vries_2020_Front.Genet_11_756 |
| Author(s) : de Vries S , de Vries J |
| Ref : Front Genet , 11 :756 , 2020 |
| Abstract : de Vries_2020_Front.Genet_11_756 |
| ESTHER : de Vries_2020_Front.Genet_11_756 |
| PubMedSearch : de Vries_2020_Front.Genet_11_756 |
| PubMedID: 32849784 |
| Title : Fungal Dirigent Protein Controls the Stereoselectivity of Multicopper Oxidase-Catalyzed Phenol Coupling in Viriditoxin Biosynthesis - Hu_2019_J.Am.Chem.Soc_141_8068 |
| Author(s) : Hu J , Li H , Chooi YH |
| Ref : Journal of the American Chemical Society , 141 :8068 , 2019 |
| Abstract : Hu_2019_J.Am.Chem.Soc_141_8068 |
| ESTHER : Hu_2019_J.Am.Chem.Soc_141_8068 |
| PubMedSearch : Hu_2019_J.Am.Chem.Soc_141_8068 |
| PubMedID: 31045362 |
| Gene_locus related to this paper: byssn-VdtD , byssp-vdta1 |
| Title : Structural traits and catalytic versatility of the lipases from the Candida rugosa-like family: A review - Barriuso_2016_Biotechnol.Adv_34_874 |
| Author(s) : Barriuso J , Vaquero ME , Prieto A , Martinez MJ |
| Ref : Biotechnol Adv , 34 :874 , 2016 |
| Abstract : Barriuso_2016_Biotechnol.Adv_34_874 |
| ESTHER : Barriuso_2016_Biotechnol.Adv_34_874 |
| PubMedSearch : Barriuso_2016_Biotechnol.Adv_34_874 |
| PubMedID: 27188926 |
| Title : Crystal structures of Ophiostoma piceae sterol esterase: Structural insights into activation mechanism and product release - Gutierrez-Fernandez_2014_J.Struct.Biol_187_215 |
| Author(s) : Gutierrez-Fernandez J , Vaquero ME , Prieto A , Barriuso J , Martinez MJ , Hermoso JA |
| Ref : J Struct Biol , 187 :215 , 2014 |
| Abstract : Gutierrez-Fernandez_2014_J.Struct.Biol_187_215 |
| ESTHER : Gutierrez-Fernandez_2014_J.Struct.Biol_187_215 |
| PubMedSearch : Gutierrez-Fernandez_2014_J.Struct.Biol_187_215 |
| PubMedID: 25108239 |
| Gene_locus related to this paper: 9pezi-q2tfw1 |
| Title : Insights into the molecular basis of chiral acid recognition by Candida rugosa lipase from an X-ray crystal structure of a bound phosphonate transition state analog - Colton_2011_Adv.Synth.Catal_353_2529 |
| Author(s) : Colton IJ , Yin DT , Grochulski P , Kazlauskas RJ |
| Ref : Adv Synth Catal , 353 :2529 , 2011 |
| Abstract : Colton_2011_Adv.Synth.Catal_353_2529 |
| ESTHER : Colton_2011_Adv.Synth.Catal_353_2529 |
| PubMedSearch : Colton_2011_Adv.Synth.Catal_353_2529 |
| PubMedID: |
| Gene_locus related to this paper: canru-1lipa |
| Title : Aspergillus niger protein EstA defines a new class of fungal esterases within the alpha\/beta hydrolase fold superfamily of proteins - Bourne_2004_Structure_12_677 |
| Author(s) : Bourne Y , Hasper AA , Chahinian H , Juin M , De Graaff LH , Marchot P |
| Ref : Structure , 12 :677 , 2004 |
| Abstract : Bourne_2004_Structure_12_677 |
| ESTHER : Bourne_2004_Structure_12_677 |
| PubMedSearch : Bourne_2004_Structure_12_677 |
| PubMedID: 15062090 |
| Gene_locus related to this paper: aspni-EstA |
| Title : Defining substrate characteristics from 3D structure\; perspective on EstA structure - Schrag_2004_Structure.(Camb)_12_521 |
| Author(s) : Schrag JD , Cygler M |
| Ref : Structure , 12 :521 , 2004 |
| Abstract : Schrag_2004_Structure.(Camb)_12_521 |
| ESTHER : Schrag_2004_Structure.(Camb)_12_521 |
| PubMedSearch : Schrag_2004_Structure.(Camb)_12_521 |
| PubMedID: 15062074 |
| Gene_locus related to this paper: aspni-EstA |
| Title : Structural insights into the lipase\/esterase behavior in the Candida rugosa lipases family: crystal structure of the lipase 2 isoenzyme at 1.97A resolution - Mancheno_2003_J.Mol.Biol_332_1059 |
| Author(s) : Mancheno JM , Pernas MA , Martinez MJ , Ochoa B , Rua ML , Hermoso JA |
| Ref : Journal of Molecular Biology , 332 :1059 , 2003 |
| Abstract : Mancheno_2003_J.Mol.Biol_332_1059 |
| ESTHER : Mancheno_2003_J.Mol.Biol_332_1059 |
| PubMedSearch : Mancheno_2003_J.Mol.Biol_332_1059 |
| PubMedID: 14499609 |
| Gene_locus related to this paper: canru-2lipa |
| Title : Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution - Pletnev_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_50 |
| Author(s) : Pletnev V , Addlagatta A , Wawrzak Z , Duax W |
| Ref : Acta Crystallographica D Biol Crystallogr , 59 :50 , 2003 |
| Abstract : Pletnev_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_50 |
| ESTHER : Pletnev_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_50 |
| PubMedSearch : Pletnev_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_50 |
| PubMedID: 12499539 |
| Gene_locus related to this paper: canru-3lipa |
| Title : Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase - Ghosh_1995_Structure_3_279 |
| Author(s) : Ghosh D , Wawrzak Z , Pletnev VZ , Li N , Kaiser R , Pangborn W , Jornvall H , Erman M , Duax WL |
| Ref : Structure , 3 :279 , 1995 |
| Abstract : Ghosh_1995_Structure_3_279 |
| ESTHER : Ghosh_1995_Structure_3_279 |
| PubMedSearch : Ghosh_1995_Structure_3_279 |
| PubMedID: 7788294 |
| Gene_locus related to this paper: canru-3lipa |
| Title : Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase - Grochulski_1994_Biochemistry_33_3494 |
| Author(s) : Grochulski P , Bouthillier F , Kazlauskas RJ , Serreqi AN , Schrag JD , Ziomek E , Cygler M |
| Ref : Biochemistry , 33 :3494 , 1994 |
| Abstract : Grochulski_1994_Biochemistry_33_3494 |
| ESTHER : Grochulski_1994_Biochemistry_33_3494 |
| PubMedSearch : Grochulski_1994_Biochemistry_33_3494 |
| PubMedID: 8142346 |
| Gene_locus related to this paper: canru-1lipa |
| Title : A structural basis for the chiral preferences of lipases - |
| Author(s) : Cygler M , Grochulski P , Kazlauskas RJ , Schrag JD , Bouthillier F , Rubin B , Serreqi AN , Gupta AK |
| Ref : Journal of the American Chemical Society , 116 :3180 , 1994 |
| PubMedID: |
| Gene_locus related to this paper: canru-1lipa |
| Title : Insights into interfacial activation from an open structure of Candida rugosa lipase - Grochulski_1993_J.Biol.Chem_268_12843 |
| Author(s) : Grochulski P , Li Y , Schrag JD , Bouthillier F , Smith P , Harrison D , Rubin B , Cygler M |
| Ref : Journal of Biological Chemistry , 268 :12843 , 1993 |
| Abstract : Grochulski_1993_J.Biol.Chem_268_12843 |
| ESTHER : Grochulski_1993_J.Biol.Chem_268_12843 |
| PubMedSearch : Grochulski_1993_J.Biol.Chem_268_12843 |
| PubMedID: 8509417 |
| Gene_locus related to this paper: canru-1lipa , geoca-1lipa |
| Title : 1.8 A refined structure of the lipase from Geotrichum candidum - Schrag_1993_J.Mol.Biol_230_575 |
| Author(s) : Schrag JD , Cygler M |
| Ref : Journal of Molecular Biology , 230 :575 , 1993 |
| Abstract : Schrag_1993_J.Mol.Biol_230_575 |
| ESTHER : Schrag_1993_J.Mol.Biol_230_575 |
| PubMedSearch : Schrag_1993_J.Mol.Biol_230_575 |
| PubMedID: 8464065 |
| Gene_locus related to this paper: geoca-1lipa , geoca-2lipa |
Structures (16)
Genes Proteins in Fungal_carboxylesterase_lipase family (4899)
Fragments of genes in Fungal_carboxylesterase_lipase family (1077)
Structures in Fungal_carboxylesterase_lipase family (16)Substrates in Fungal_carboxylesterase_lipase family (27)
Inhibitors in Fungal_carboxylesterase_lipase family (5)