Fungal-Bact_LIP
Relationship
Comment
Secretory lipases. Fungal-Bact_LIP is a new family as described by Neugnot et al. and Hube et al. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue. CalA is highly unusual in that it accepts tertiary alcohols and shows a high selectivity for the N-acylation of beta-amino esters. It has also amidase activity. Bassegoda et al. defined the bacterial members of this family as Family X.2 of Bacterial lipases (Family 10.2 in the updated classification of Arpigny et Jaeger (1999) ). Castilla et al. Defined a new lipase family (Family XVII) (Family 17) with a novel thermophilic and halophilic esterase from Janibacter sp. R02 as the first member of this subfamily. Parapouli et al. analysed a new thermostable alkaliphilic lipase LipSm from Stenotrophomonas maltophilia. These authors created a new family XIX for homologues of this enzymeDatabase
Interpro : IPR005152 Lipase_secreted
PIRSF : PIRSF029171 secreted esterase, Lip1 type Esterase_LipA
Pdoc : No Pdoc
Pfam : PF03583 LIP
Prints : No Print
EC Number : No EC Number
References (17)
| Title : Phylogenetic analyses reveal insights into interdomain horizontal gene transfer of microbial lipases - Medeiros_2024_Mol.Phylogenet.Evol__108069 |
| Author(s) : Medeiros P , Canato D , Sergio Kimus Braz A , Campos Paulino L |
| Ref : Mol Phylogenet Evol , :108069 , 2024 |
| Abstract : Medeiros_2024_Mol.Phylogenet.Evol__108069 |
| ESTHER : Medeiros_2024_Mol.Phylogenet.Evol__108069 |
| PubMedSearch : Medeiros_2024_Mol.Phylogenet.Evol__108069 |
| PubMedID: 38565359 |
| Title : Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi-1, the first member of a new bacterial lipase family (XIX) - Parapouli_2018_J.Biol.Res.(Thessalon)_25_4 |
| Author(s) : Parapouli M , Foukis A , Stergiou PY , Koukouritaki M , Magklaras P , Gkini OA , Papamichael EM , Afendra AS , Hatziloukas E |
| Ref : J Biol Res (Thessalon) , 25 :4 , 2018 |
| Abstract : Parapouli_2018_J.Biol.Res.(Thessalon)_25_4 |
| ESTHER : Parapouli_2018_J.Biol.Res.(Thessalon)_25_4 |
| PubMedSearch : Parapouli_2018_J.Biol.Res.(Thessalon)_25_4 |
| PubMedID: 29456971 |
| Gene_locus related to this paper: stema-a0a218l045 |
| Title : A glimpse into the specialization history of the lipases\/acyltransferases family of CpLIP2 - Jan_2017_Biochim.Biophys.Acta_1865_1105 |
| Author(s) : Jan AH , Dubreucq E , Drone J , Subileau M |
| Ref : Biochimica & Biophysica Acta , 1865 :1105 , 2017 |
| Abstract : Jan_2017_Biochim.Biophys.Acta_1865_1105 |
| ESTHER : Jan_2017_Biochim.Biophys.Acta_1865_1105 |
| PubMedSearch : Jan_2017_Biochim.Biophys.Acta_1865_1105 |
| PubMedID: 28627478 |
| Gene_locus related to this paper: canpa-LIP2 , cantt-c5mag0 |
| Title : A novel thermophilic and halophilic esterase from Janibacter sp. R02, the first member of a new lipase family (Family XVII) - Castilla_2017_Enzyme.Microb.Technol_98_86 |
| Author(s) : Castilla A , Panizza P , Rodriguez D , Bonino L , Diaz P , Irazoqui G , Rodriguez Giordano S |
| Ref : Enzyme Microb Technol , 98 :86 , 2017 |
| Abstract : Castilla_2017_Enzyme.Microb.Technol_98_86 |
| ESTHER : Castilla_2017_Enzyme.Microb.Technol_98_86 |
| PubMedSearch : Castilla_2017_Enzyme.Microb.Technol_98_86 |
| PubMedID: 28110668 |
| Gene_locus related to this paper: 9mico-a0a1s5r222 |
| Title : The Type II Secreted Lipase\/Esterase LesA is a Key Virulence Factor Required for Xylella fastidiosa Pathogenesis in Grapevines - Nascimento_2016_Sci.Rep_6_18598 |
| Author(s) : Nascimento R , Gouran H , Chakraborty S , Gillespie HW , Almeida-Souza HO , Tu A , Rao BJ , Feldstein PA , Bruening G , Goulart LR , Dandekar AM |
| Ref : Sci Rep , 6 :18598 , 2016 |
| Abstract : Nascimento_2016_Sci.Rep_6_18598 |
| ESTHER : Nascimento_2016_Sci.Rep_6_18598 |
| PubMedSearch : Nascimento_2016_Sci.Rep_6_18598 |
| PubMedID: 26753904 |
| Gene_locus related to this paper: xylfa-XF0357 |
| Title : Rhodococcus sp. Strain CR-53 LipR, the First Member of a New Bacterial Lipase Family (Family X) Displaying an Unusual Y-Type Oxyanion Hole, Similar to the Candida antarctica Lipase Clan - Bassegoda_2012_Appl.Environ.Microbiol_78_1724 |
| Author(s) : Bassegoda A , Pastor FI , Diaz P |
| Ref : Applied Environmental Microbiology , 78 :1724 , 2012 |
| Abstract : Bassegoda_2012_Appl.Environ.Microbiol_78_1724 |
| ESTHER : Bassegoda_2012_Appl.Environ.Microbiol_78_1724 |
| PubMedSearch : Bassegoda_2012_Appl.Environ.Microbiol_78_1724 |
| PubMedID: 22226953 |
| Gene_locus related to this paper: 9noca-g0w2h6 |
| Title : The short form of the recombinant CAL-A-type lipase UM03410 from the smut fungus Ustilago maydis exhibits an inherent trans-fatty acid selectivity - Brundiek_2012_Appl.Microbiol.Biotechnol_94_141 |
| Author(s) : Brundiek H , Sass S , Evitt A , Kourist R , Bornscheuer UT |
| Ref : Applied Microbiology & Biotechnology , 94 :141 , 2012 |
| Abstract : Brundiek_2012_Appl.Microbiol.Biotechnol_94_141 |
| ESTHER : Brundiek_2012_Appl.Microbiol.Biotechnol_94_141 |
| PubMedSearch : Brundiek_2012_Appl.Microbiol.Biotechnol_94_141 |
| PubMedID: 22294433 |
| Gene_locus related to this paper: ustma-q4p903 |
| Title : Creation of a lipase highly selective for trans fatty acids by protein engineering - Brundiek_2012_Angew.Chem.Int.Ed.Engl_51_412 |
| Author(s) : Brundiek HB , Evitt AS , Kourist R , Bornscheuer UT |
| Ref : Angew Chem Int Ed Engl , 51 :412 , 2012 |
| Abstract : Brundiek_2012_Angew.Chem.Int.Ed.Engl_51_412 |
| ESTHER : Brundiek_2012_Angew.Chem.Int.Ed.Engl_51_412 |
| PubMedSearch : Brundiek_2012_Angew.Chem.Int.Ed.Engl_51_412 |
| PubMedID: 22113941 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Protein engineering of alpha\/beta-hydrolase fold enzymes - Jochens_2011_Chembiochem_12_1508 |
| Author(s) : Jochens H , Hesseler M , Stiba K , Padhi SK , Kazlauskas RJ , Bornscheuer UT |
| Ref : Chembiochem , 12 :1508 , 2011 |
| Abstract : Jochens_2011_Chembiochem_12_1508 |
| ESTHER : Jochens_2011_Chembiochem_12_1508 |
| PubMedSearch : Jochens_2011_Chembiochem_12_1508 |
| PubMedID: 21506229 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Suppression of water as a nucleophile in Candida antarctica lipase B catalysis - Larsen_2010_Chembiochem_11_796 |
| Author(s) : Larsen MW , Zielinska DF , Martinelle M , Hidalgo A , Jensen LJ , Bornscheuer UT , Hult K |
| Ref : Chembiochem , 11 :796 , 2010 |
| Abstract : Larsen_2010_Chembiochem_11_796 |
| ESTHER : Larsen_2010_Chembiochem_11_796 |
| PubMedSearch : Larsen_2010_Chembiochem_11_796 |
| PubMedID: 20235107 |
| Gene_locus related to this paper: canan-lipasA |
| Title : Formation and hydrolysis of amide bonds by lipase A from Candida antarctica\; exceptional features - Liljeblad_2010_Org.Biomol.Chem_8_886 |
| Author(s) : Liljeblad A , Kallio P , Vainio M , Niemi J , Kanerva LT |
| Ref : Org Biomol Chem , 8 :886 , 2010 |
| Abstract : Liljeblad_2010_Org.Biomol.Chem_8_886 |
| ESTHER : Liljeblad_2010_Org.Biomol.Chem_8_886 |
| PubMedSearch : Liljeblad_2010_Org.Biomol.Chem_8_886 |
| PubMedID: 20135048 |
| Gene_locus related to this paper: canan-lipasA |
| Title : A cell wall-degrading esterase of Xanthomonas oryzae requires a unique substrate recognition module for pathogenesis on rice - Aparna_2009_Plant.Cell_21_1860 |
| Author(s) : Aparna G , Chatterjee A , Sonti RV , Sankaranarayanan R |
| Ref : Plant Cell , 21 :1860 , 2009 |
| Abstract : Aparna_2009_Plant.Cell_21_1860 |
| ESTHER : Aparna_2009_Plant.Cell_21_1860 |
| PubMedSearch : Aparna_2009_Plant.Cell_21_1860 |
| PubMedID: 19525415 |
| Gene_locus related to this paper: xanor-q5h5j0 |
| Title : Enzymatic removal of carboxyl protecting groups. 1. Cleavage of the tert-butyl moiety - Schmidt_2005_J.Org.Chem_70_3737 |
| Author(s) : Schmidt M , Barbayianni E , Fotakopoulou I , Hohne M , Constantinou-Kokotou V , Bornscheuer UT , Kokotos G |
| Ref : J Org Chem , 70 :3737 , 2005 |
| Abstract : Schmidt_2005_J.Org.Chem_70_3737 |
| ESTHER : Schmidt_2005_J.Org.Chem_70_3737 |
| PubMedSearch : Schmidt_2005_J.Org.Chem_70_3737 |
| PubMedID: 15845019 |
| Gene_locus related to this paper: canan-lipasA |
| Title : The lipase\/acyltransferase from Candida parapsilosis: molecular cloning and characterization of purified recombinant enzymes - Neugnot_2002_Eur.J.Biochem_269_1734 |
| Author(s) : Neugnot V , Moulin G , Dubreucq E , Bigey F |
| Ref : European Journal of Biochemistry , 269 :1734 , 2002 |
| Abstract : Neugnot_2002_Eur.J.Biochem_269_1734 |
| ESTHER : Neugnot_2002_Eur.J.Biochem_269_1734 |
| PubMedSearch : Neugnot_2002_Eur.J.Biochem_269_1734 |
| PubMedID: 11895444 |
| Gene_locus related to this paper: canpa-LIP1 , canpa-LIP2 |
| Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| Author(s) : Jaeger KE , Eggert T |
| Ref : Curr Opin Biotechnol , 13 :390 , 2002 |
| Abstract : Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| ESTHER : Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| PubMedSearch : Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| PubMedID: 12323363 |
| Title : Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members - Hube_2000_Arch.Microbiol_174_362 |
| Author(s) : Hube B , Stehr F , Bossenz M , Mazur A , Kretschmar M , Schafer W |
| Ref : Arch Microbiol , 174 :362 , 2000 |
| Abstract : Hube_2000_Arch.Microbiol_174_362 |
| ESTHER : Hube_2000_Arch.Microbiol_174_362 |
| PubMedSearch : Hube_2000_Arch.Microbiol_174_362 |
| PubMedID: 11131027 |
| Gene_locus related to this paper: canal-LIP1 , canal-LIP2 , canal-LIP3 , canal-LIP4 , canal-LIP5 , canal-LIP6 , canal-LIP7 , canal-LIP8 , canal-LIP9 , canal-LIP10 |
| Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177 |
| Author(s) : Arpigny JL , Jaeger KE |
| Ref : Biochemical Journal , 343 :177 , 1999 |
| Abstract : Arpigny_1999_Biochem.J_343_177 |
| ESTHER : Arpigny_1999_Biochem.J_343_177 |
| PubMedSearch : Arpigny_1999_Biochem.J_343_177 |
| PubMedID: 10493927 |
Structures (9)
Genes Proteins in Fungal-Bact_LIP family (413)
Fragments of genes in Fungal-Bact_LIP family (5)
Structures in Fungal-Bact_LIP family (9)Substrates in Fungal-Bact_LIP family (11)
Inhibitors in Fungal-Bact_LIP family (7)