CMBL

Relationship

Family: CMBL

Block: X

Parent Family: No family

Comment

(from Interpro) Carboxymethylenebutenolidase (CMBL) is a human homologue of Pseudomonas dienelactone hydrolase involved in the bacterial halocatechol degradation pathway. It is a cysteine hydrolase that can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Not inhibited by DFP, PMSF, eserine or EDTA. Strongly inhibited by p-chloromercuribenzoate (PCMB). This entry also includes uncharacterised DLH domain-containing proteins from plants. This family was previously included in Dienelactone_hydrolase

Database

Interpro : IPR042946 Carboxymethylenebutenolidase homolog

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in	Fasta
Nucleotide in	Fasta
Alignment with Multalin	Text only
Seed alignment with MAFFT	No colour
Alignment with MAFFT	No colour
Dendrogram	The dnd file

References (2)

Title : Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine - Ishizuka_2013_Drug.Metab.Dispos_41_1156

Author(s) : Ishizuka T , Rozehnal V , Fischer T , Kato A , Endo S , Yoshigae Y , Kurihara A , Izumi T

Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1156 , 2013

Abstract : Ishizuka_2013_Drug.Metab.Dispos_41_1156

ESTHER : Ishizuka_2013_Drug.Metab.Dispos_41_1156

PubMedSearch : Ishizuka_2013_Drug.Metab.Dispos_41_1156

PubMedID: 23471504

Gene_locus related to this paper: human-CMBL

Title : Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine - Ishizuka_2010_J.Biol.Chem_285_11892

Author(s) : Ishizuka T , Fujimori I , Kato M , Noji-Sakikawa C , Saito M , Yoshigae Y , Kubota K , Kurihara A , Izumi T , Ikeda T , Okazaki O

Ref : Journal of Biological Chemistry , 285 :11892 , 2010

Abstract : Ishizuka_2010_J.Biol.Chem_285_11892

ESTHER : Ishizuka_2010_J.Biol.Chem_285_11892

PubMedSearch : Ishizuka_2010_J.Biol.Chem_285_11892

PubMedID: 20177059

Gene_locus related to this paper: human-CMBL

No structure scheme yet for this family

Genes Proteins in CMBL family (251)

Fragments of genes in CMBL family (32)

No fragment of genes

Substrates in CMBL family (2)

No Inhibitor