ACPH_Peptidase_S9
Relationship
Comment
Merops Subfamily S9C. Acylamino-acid-releasing enzyme ACPH APEH. This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. ACPH_Peptidase_S9: VPA-glucuronidase is responsible for maintaining the serum concentration of VPA, by cleaving its major metabolic product, valproic acid-beta-(d)-glucuronide (VPA-G),2 releasing VPA allowing its reabsorption. This enzyme is inhibited by carbapenems. Other names: oxidized protein hydrolase (OPH), acylamino-acid-releasing enzyme, N-formylmethionyl-peptidase, acylpeptide-hydrolase (APEH)acylaminoacyl peptidase (AAP)Database
Interpro : IPR001375 Peptidase_S9 , IPR011042 6-blade_b-propeller_TolB-like
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00326 Peptidase_S9
Prints : No Print
EC Number : No EC Number
References (8)
| Title : A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase-meropenem complex - Kiss-Szeman_2022_Chem.Sci_13_14264 |
| Author(s) : Kiss-Szeman AJ , Takacs L , Orgovan Z , Straner P , Jakli I , Schlosser G , Masiulis S , Harmat V , Menyhard DK , Perczel A |
| Ref : Chem Sci , 13 :14264 , 2022 |
| Abstract : Kiss-Szeman_2022_Chem.Sci_13_14264 |
| ESTHER : Kiss-Szeman_2022_Chem.Sci_13_14264 |
| PubMedSearch : Kiss-Szeman_2022_Chem.Sci_13_14264 |
| PubMedID: 36545146 |
| Gene_locus related to this paper: pig-acph |
| Title : Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase - Fage_2016_Angew.Chem.Int.Ed.Engl_55_12717 |
| Author(s) : Fage CD , Hegemann JD , Nebel AJ , Steinbach RM , Zhu S , Linne U , Harms K , Bange G , Marahiel MA |
| Ref : Angew Chem Int Ed Engl , 55 :12717 , 2016 |
| Abstract : Fage_2016_Angew.Chem.Int.Ed.Engl_55_12717 |
| ESTHER : Fage_2016_Angew.Chem.Int.Ed.Engl_55_12717 |
| PubMedSearch : Fage_2016_Angew.Chem.Int.Ed.Engl_55_12717 |
| PubMedID: 27611791 |
| Gene_locus related to this paper: sphal-q1gq33 |
| Title : Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates - Chekan_2016_J.Am.Chem.Soc_138_16452 |
| Author(s) : Chekan JR , Koos JD , Zong C , Maksimov MO , Link AJ , Nair SK |
| Ref : Journal of the American Chemical Society , 138 :16452 , 2016 |
| Abstract : Chekan_2016_J.Am.Chem.Soc_138_16452 |
| ESTHER : Chekan_2016_J.Am.Chem.Soc_138_16452 |
| PubMedSearch : Chekan_2016_J.Am.Chem.Soc_138_16452 |
| PubMedID: 27998080 |
| Gene_locus related to this paper: astec-e8rup5 |
| Title : Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality - Menyhard_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_461 |
| Author(s) : Menyhard DK , Orgovan Z , Szeltner Z , Szamosi I , Harmat V |
| Ref : Acta Crystallographica D Biol Crystallogr , 71 :461 , 2015 |
| Abstract : Menyhard_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_461 |
| ESTHER : Menyhard_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_461 |
| PubMedSearch : Menyhard_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_461 |
| PubMedID: 25760596 |
| Gene_locus related to this paper: aerpe-APE1547 |
| Title : A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization - Menyhard_2013_J.Biol.Chem_288_17884 |
| Author(s) : Menyhard DK , Kiss-Szeman A , Tichy-Racs E , Hornung B , Radi K , Szeltner Z , Domokos K , Szamosi I , Naray-Szabo G , Polgar L , Harmat V |
| Ref : Journal of Biological Chemistry , 288 :17884 , 2013 |
| Abstract : Menyhard_2013_J.Biol.Chem_288_17884 |
| ESTHER : Menyhard_2013_J.Biol.Chem_288_17884 |
| PubMedSearch : Menyhard_2013_J.Biol.Chem_288_17884 |
| PubMedID: 23632025 |
| Gene_locus related to this paper: pyrho-PH0594 |
| Title : Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics - Suzuki_2010_Drug.Metab.Dispos_38_1538 |
| Author(s) : Suzuki E , Yamamura N , Ogura Y , Nakai D , Kubota K , Kobayashi N , Miura S , Okazaki O |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 38 :1538 , 2010 |
| Abstract : Suzuki_2010_Drug.Metab.Dispos_38_1538 |
| ESTHER : Suzuki_2010_Drug.Metab.Dispos_38_1538 |
| PubMedSearch : Suzuki_2010_Drug.Metab.Dispos_38_1538 |
| PubMedID: 20551238 |
| Title : Discrimination of esterase and peptidase activities of acylaminoacyl peptidase from hyperthermophilic Aeropyrum pernix K1 by a single mutation - Wang_2006_J.Biol.Chem_281_18618 |
| Author(s) : Wang Q , Yang G , Liu Y , Feng Y |
| Ref : Journal of Biological Chemistry , 281 :18618 , 2006 |
| Abstract : Wang_2006_J.Biol.Chem_281_18618 |
| ESTHER : Wang_2006_J.Biol.Chem_281_18618 |
| PubMedSearch : Wang_2006_J.Biol.Chem_281_18618 |
| PubMedID: 16670095 |
| Gene_locus related to this paper: aerpe-APE1547 |
| Title : Crystal Structure of an Acylpeptide Hydrolase\/Esterase from Aeropyrum pernix K1. - Bartlam_2004_Structure.(Camb)_12_1481 |
| Author(s) : Bartlam M , Wang G , Yang H , Gao R , Zhao X , Xie G , Cao S , Feng Y , Rao Z |
| Ref : Structure(Camb) , 12 :1481 , 2004 |
| Abstract : Bartlam_2004_Structure.(Camb)_12_1481 |
| ESTHER : Bartlam_2004_Structure.(Camb)_12_1481 |
| PubMedSearch : Bartlam_2004_Structure.(Camb)_12_1481 |
| PubMedID: 15296741 |
| Gene_locus related to this paper: aerpe-APE1547 |
Structures (31)
Genes Proteins in ACPH_Peptidase_S9 family (140)
Fragments of genes in ACPH_Peptidase_S9 family (6)
Structures in ACPH_Peptidase_S9 family (31)Substrates in ACPH_Peptidase_S9 family (8)
Inhibitors in ACPH_Peptidase_S9 family (20)