Thioesterase
Relationship
Comment
Thioesterase domains often occur integrated in or associated with peptide synthetases which are involved in the non-ribosomal synthesis of peptide antibiotics. Thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Only the last domain TE thioesterase of the acv synthetase (acvs) is included in ESTHER (Polyketide synthase Polyene PKS). Human fatty acid synthase (FAS) is uniquely expressed at high levels in many tumor types. Pharmacological inhibition of FAS therefore represents an important therapeutic opportunity. The drug Orlistat, which has been approved by the US Food and Drug Administration, inhibits FAS, induces tumor cell-specific apoptosis. Families TE-16 TE-17 TE-18 in ThYme databaseDatabase
Interpro : IPR001031 Thioesterase , IPR012223 Thioesterase type II, NRPS\/PKS\/S-FAS TEII , IPR023102 Fatty acid synthase, domain 2 Fatty_acid_synthase_dom_2 , IPR011412 Coronamic acid biosynthesis thioesterase CmaT , IPR020802 Polyketide synthase, thioesterase domain , IPR012367 Uncharacterised conserved protein thioesterase UCP_Testerase
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00975 Thioesterase
Prints : No Print
EC Number : No EC Number
References (34)
| Title : Structural and Mechanistic Insights into Chain Release of the Polyene PKS Thioesterase Domain - Zhou_2022_ACS.Catal_12_762 |
| Author(s) : Zhou Y , Tao W , Qi Z , Wei J , Shi T , Kang Q , Zheng J , Zhao Y , Bai L |
| Ref : ACS Catal , 12 :762 , 2022 |
| Abstract : Zhou_2022_ACS.Catal_12_762 |
| ESTHER : Zhou_2022_ACS.Catal_12_762 |
| PubMedSearch : Zhou_2022_ACS.Catal_12_762 |
| PubMedID: |
| Gene_locus related to this paper: 9actn-f1cla7 |
| Title : Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis - Little_2022_Nat.Prod.Rep_39_163 |
| Author(s) : Little RF , Hertweck C |
| Ref : Nat Prod Rep , 39 :163 , 2022 |
| Abstract : Little_2022_Nat.Prod.Rep_39_163 |
| ESTHER : Little_2022_Nat.Prod.Rep_39_163 |
| PubMedSearch : Little_2022_Nat.Prod.Rep_39_163 |
| PubMedID: 34622896 |
| Title : Thioesterase enzyme families: Functions, structures, and mechanisms - Caswell_2021_Protein.Sci__ |
| Author(s) : Caswell BT , de Carvalho CC , Nguyen H , Roy M , Nguyen T , Cantu DC |
| Ref : Protein Science , : , 2021 |
| Abstract : Caswell_2021_Protein.Sci__ |
| ESTHER : Caswell_2021_Protein.Sci__ |
| PubMedSearch : Caswell_2021_Protein.Sci__ |
| PubMedID: 34921469 |
| Title : Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid - Huguenin-Dezot_2019_Nature_565_112 |
| Author(s) : Huguenin-Dezot N , Alonzo DA , Heberlig GW , Mahesh M , Nguyen DP , Dornan MH , Boddy CN , Schmeing TM , Chin JW |
| Ref : Nature , 565 :112 , 2019 |
| Abstract : Huguenin-Dezot_2019_Nature_565_112 |
| ESTHER : Huguenin-Dezot_2019_Nature_565_112 |
| PubMedSearch : Huguenin-Dezot_2019_Nature_565_112 |
| PubMedID: 30542153 |
| Gene_locus related to this paper: 9acto-q1psf3 |
| Title : Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate? - Horsman_2016_Nat.Prod.Rep_33_183 |
| Author(s) : Horsman ME , Hari TP , Boddy CN |
| Ref : Nat Prod Rep , 33 :183 , 2016 |
| Abstract : Horsman_2016_Nat.Prod.Rep_33_183 |
| ESTHER : Horsman_2016_Nat.Prod.Rep_33_183 |
| PubMedSearch : Horsman_2016_Nat.Prod.Rep_33_183 |
| PubMedID: 25642666 |
| Title : Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture - Miller_2016_J.Biol.Chem_291_22559 |
| Author(s) : Miller BR , Drake EJ , Shi C , Aldrich CC , Gulick AM |
| Ref : Journal of Biological Chemistry , 291 :22559 , 2016 |
| Abstract : Miller_2016_J.Biol.Chem_291_22559 |
| ESTHER : Miller_2016_J.Biol.Chem_291_22559 |
| PubMedSearch : Miller_2016_J.Biol.Chem_291_22559 |
| PubMedID: 27597544 |
| Gene_locus related to this paper: ecoli-entf |
| Title : Structures of two distinct conformations of holo-non-ribosomal peptide synthetases - Drake_2016_Nature_529_235 |
| Author(s) : Drake EJ , Miller BR , Shi C , Tarrasch JT , Sundlov JA , Allen CL , Skiniotis G , Aldrich CC , Gulick AM |
| Ref : Nature , 529 :235 , 2016 |
| Abstract : Drake_2016_Nature_529_235 |
| ESTHER : Drake_2016_Nature_529_235 |
| PubMedSearch : Drake_2016_Nature_529_235 |
| PubMedID: 26762461 |
| Gene_locus related to this paper: aciba-AB3403 , ecoli-entf |
| Title : Crystal Structure and Substrate Specificity of Human Thioesterase 2: Insights into the Molecular Basis for the Modulation of Fatty Acid Synthase - Ritchie_2016_J.Biol.Chem_291_3520 |
| Author(s) : Ritchie MK , Johnson LC , Clodfelter JE , Pemble CWt , Fulp BE , Furdui CM , Kridel SJ , Lowther WT |
| Ref : Journal of Biological Chemistry , 291 :3520 , 2016 |
| Abstract : Ritchie_2016_J.Biol.Chem_291_3520 |
| ESTHER : Ritchie_2016_J.Biol.Chem_291_3520 |
| PubMedSearch : Ritchie_2016_J.Biol.Chem_291_3520 |
| PubMedID: 26663084 |
| Gene_locus related to this paper: human-OLAH |
| Title : Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis - Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
| Author(s) : Argyropoulos P , Bergeret F , Pardin C , Reimer JM , Pinto A , Boddy CN , Schmeing TM |
| Ref : Biochimica & Biophysica Acta , 1860 :486 , 2016 |
| Abstract : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
| ESTHER : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
| PubMedSearch : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
| PubMedID: 26592346 |
| Gene_locus related to this paper: sacer-ery3 |
| Title : Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis - Park_2015_J.Chem.Inf.Model_55_1914 |
| Author(s) : Park IH , Venable JD , Steckler C , Cellitti SE , Lesley SA , Spraggon G , Brock A |
| Ref : J Chem Inf Model , 55 :1914 , 2015 |
| Abstract : Park_2015_J.Chem.Inf.Model_55_1914 |
| ESTHER : Park_2015_J.Chem.Inf.Model_55_1914 |
| PubMedSearch : Park_2015_J.Chem.Inf.Model_55_1914 |
| PubMedID: 26241692 |
| Gene_locus related to this paper: human-FASN |
| Title : Rational reprogramming of fungal polyketide first-ring cyclization - Xu_2013_Proc.Natl.Acad.Sci.U.S.A_110_5398 |
| Author(s) : Xu Y , Zhou T , Zhou Z , Su S , Roberts SA , Montfort WR , Zeng J , Chen M , Zhang W , Lin M , Zhan J , Molnar I |
| Ref : Proc Natl Acad Sci U S A , 110 :5398 , 2013 |
| Abstract : Xu_2013_Proc.Natl.Acad.Sci.U.S.A_110_5398 |
| ESTHER : Xu_2013_Proc.Natl.Acad.Sci.U.S.A_110_5398 |
| PubMedSearch : Xu_2013_Proc.Natl.Acad.Sci.U.S.A_110_5398 |
| PubMedID: 23509261 |
| Gene_locus related to this paper: aspte-curs2 , floch-rads2 |
| Title : Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis - Xu_2013_J.Am.Chem.Soc_135_10783 |
| Author(s) : Xu Y , Zhou T , Zhang S , Xuan LJ , Zhan J , Molnar I |
| Ref : Journal of the American Chemical Society , 135 :10783 , 2013 |
| Abstract : Xu_2013_J.Am.Chem.Soc_135_10783 |
| ESTHER : Xu_2013_J.Am.Chem.Soc_135_10783 |
| PubMedSearch : Xu_2013_J.Am.Chem.Soc_135_10783 |
| PubMedID: 23822773 |
| Gene_locus related to this paper: aspte-curs2 , floch-rads2 |
| Title : Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases. - Liu_2011_Chem.Biol_18_1482 |
| Author(s) : Liu Y , Zheng T , Bruner SD |
| Ref : Chemical Biology , 18 :1482 , 2011 |
| Abstract : Liu_2011_Chem.Biol_18_1482 |
| ESTHER : Liu_2011_Chem.Biol_18_1482 |
| PubMedSearch : Liu_2011_Chem.Biol_18_1482 |
| PubMedID: 22118682 |
| Gene_locus related to this paper: ecoli-entf |
| Title : ThYme: a database for thioester-active enzymes - Cantu_2011_Nucleic.Acids.Res_39_D342 |
| Author(s) : Cantu DC , Chen Y , Lemons ML , Reilly PJ |
| Ref : Nucleic Acids Research , 39 :D342 , 2011 |
| Abstract : Cantu_2011_Nucleic.Acids.Res_39_D342 |
| ESTHER : Cantu_2011_Nucleic.Acids.Res_39_D342 |
| PubMedSearch : Cantu_2011_Nucleic.Acids.Res_39_D342 |
| PubMedID: 21045059 |
| Title : Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid - Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| Author(s) : Zhang W , Chakravarty B , Zheng F , Gu Z , Wu H , Mao J , Wakil SJ , Quiocho FA |
| Ref : Proc Natl Acad Sci U S A , 108 :15757 , 2011 |
| Abstract : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| ESTHER : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| PubMedSearch : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| PubMedID: 21908709 |
| Gene_locus related to this paper: human-FASN |
| Title : Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor - Whicher_2011_J.Biol.Chem_286_22558 |
| Author(s) : Whicher JR , Florova G , Sydor PK , Singh R , Alhamadsheh M , Challis GL , Reynolds KA , Smith JL |
| Ref : Journal of Biological Chemistry , 286 :22558 , 2011 |
| Abstract : Whicher_2011_J.Biol.Chem_286_22558 |
| ESTHER : Whicher_2011_J.Biol.Chem_286_22558 |
| PubMedSearch : Whicher_2011_J.Biol.Chem_286_22558 |
| PubMedID: 21543318 |
| Gene_locus related to this paper: strco-SC3F7.14 |
| Title : Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis - Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246 |
| Author(s) : Korman TP , Crawford JM , Labonte JW , Newman AG , Wong J , Townsend CA , Tsai SC |
| Ref : Proc Natl Acad Sci U S A , 107 :6246 , 2010 |
| Abstract : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246 |
| ESTHER : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246 |
| PubMedSearch : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246 |
| PubMedID: 20332208 |
| Gene_locus related to this paper: aspor-PKSL1 |
| Title : Thioesterases: a new perspective based on their primary and tertiary structures. - Cantu_2010_Protein.Sci_19_1281 |
| Author(s) : Cantu DC , Chen Y , Reilly PJ |
| Ref : Protein Science , 19 :1281 , 2010 |
| Abstract : Cantu_2010_Protein.Sci_19_1281 |
| ESTHER : Cantu_2010_Protein.Sci_19_1281 |
| PubMedSearch : Cantu_2010_Protein.Sci_19_1281 |
| PubMedID: 20506386 |
| Title : Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase - |
| Author(s) : Scaglione JB , Akey DL , Sullivan R , Kittendorf JD , Rath CM , Kim ES , Smith JL , Sherman DH |
| Ref : Angew Chem Int Ed Engl , 49 :5726 , 2010 |
| PubMedID: 20623733 |
| Gene_locus related to this paper: 9acto-C6ZCS0 |
| Title : Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway - Claxton_2009_J.Biol.Chem_284_5021 |
| Author(s) : Claxton HB , Akey DL , Silver MK , Admiraal SJ , Smith JL |
| Ref : Journal of Biological Chemistry , 284 :5021 , 2009 |
| Abstract : Claxton_2009_J.Biol.Chem_284_5021 |
| ESTHER : Claxton_2009_J.Biol.Chem_284_5021 |
| PubMedSearch : Claxton_2009_J.Biol.Chem_284_5021 |
| PubMedID: 19103602 |
| Gene_locus related to this paper: amyme-RIFR |
| Title : Structural basis for the selectivity of the external thioesterase of the surfactin synthetase - Koglin_2008_Nature_454_907 |
| Author(s) : Koglin A , Lohr F , Bernhard F , Rogov VV , Frueh DP , Strieter ER , Mofid MR , Guntert P , Wagner G , Walsh CT , Marahiel MA , Dotsch V |
| Ref : Nature , 454 :907 , 2008 |
| Abstract : Koglin_2008_Nature_454_907 |
| ESTHER : Koglin_2008_Nature_454_907 |
| PubMedSearch : Koglin_2008_Nature_454_907 |
| PubMedID: 18704089 |
| Gene_locus related to this paper: bacsu-srf4 |
| Title : Crystal structure of the termination module of a nonribosomal peptide synthetase - Tanovic_2008_Science_321_659 |
| Author(s) : Tanovic A , Samel SA , Essen LO , Marahiel MA |
| Ref : Science , 321 :659 , 2008 |
| Abstract : Tanovic_2008_Science_321_659 |
| ESTHER : Tanovic_2008_Science_321_659 |
| PubMedSearch : Tanovic_2008_Science_321_659 |
| PubMedID: 18583577 |
| Gene_locus related to this paper: bacsu-srfac |
| Title : Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase - Frueh_2008_Nature_454_903 |
| Author(s) : Frueh DP , Arthanari H , Koglin A , Vosburg DA , Bennett AE , Walsh CT , Wagner G |
| Ref : Nature , 454 :903 , 2008 |
| Abstract : Frueh_2008_Nature_454_903 |
| ESTHER : Frueh_2008_Nature_454_903 |
| PubMedSearch : Frueh_2008_Nature_454_903 |
| PubMedID: 18704088 |
| Gene_locus related to this paper: ecoli-entf |
| Title : The crystal structure of a mammalian fatty acid synthase - Maier_2008_Science_321_1315 |
| Author(s) : Maier T , Leibundgut M , Ban N |
| Ref : Science , 321 :1315 , 2008 |
| Abstract : Maier_2008_Science_321_1315 |
| ESTHER : Maier_2008_Science_321_1315 |
| PubMedSearch : Maier_2008_Science_321_1315 |
| PubMedID: 18772430 |
| Gene_locus related to this paper: pig-q58g70 |
| Title : Deconstruction of iterative multidomain polyketide synthase function - Crawford_2008_Science_320_243 |
| Author(s) : Crawford JM , Thomas PM , Scheerer JR , Vagstad AL , Kelleher NL , Townsend CA |
| Ref : Science , 320 :243 , 2008 |
| Abstract : Crawford_2008_Science_320_243 |
| ESTHER : Crawford_2008_Science_320_243 |
| PubMedSearch : Crawford_2008_Science_320_243 |
| PubMedID: 18403714 |
| Gene_locus related to this paper: aspor-PKSL1 , asppa-q6ueg5 |
| Title : Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat - Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
| Author(s) : Pemble CWt , Johnson LC , Kridel SJ , Lowther WT |
| Ref : Nat Struct Mol Biol , 14 :704 , 2007 |
| Abstract : Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
| ESTHER : Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
| PubMedSearch : Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
| PubMedID: 17618296 |
| Gene_locus related to this paper: human-FASN |
| Title : Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels - Giraldes_2006_Nat.Chem.Biol_2_531 |
| Author(s) : Giraldes JW , Akey DL , Kittendorf JD , Sherman DH , Smith JL , Fecik RA |
| Ref : Nat Chemical Biology , 2 :531 , 2006 |
| Abstract : Giraldes_2006_Nat.Chem.Biol_2_531 |
| ESTHER : Giraldes_2006_Nat.Chem.Biol_2_531 |
| PubMedSearch : Giraldes_2006_Nat.Chem.Biol_2_531 |
| PubMedID: 16969373 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Structural basis for macrolactonization by the pikromycin thioesterase - Akey_2006_Nat.Chem.Biol_2_537 |
| Author(s) : Akey DL , Kittendorf JD , Giraldes JW , Fecik RA , Sherman DH , Smith JL |
| Ref : Nat Chemical Biology , 2 :537 , 2006 |
| Abstract : Akey_2006_Nat.Chem.Biol_2_537 |
| ESTHER : Akey_2006_Nat.Chem.Biol_2_537 |
| PubMedSearch : Akey_2006_Nat.Chem.Biol_2_537 |
| PubMedID: 16969372 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide - Samel_2006_J.Mol.Biol_359_876 |
| Author(s) : Samel SA , Wagner B , Marahiel MA , Essen LO |
| Ref : Journal of Molecular Biology , 359 :876 , 2006 |
| Abstract : Samel_2006_J.Mol.Biol_359_876 |
| ESTHER : Samel_2006_J.Mol.Biol_359_876 |
| PubMedSearch : Samel_2006_J.Mol.Biol_359_876 |
| PubMedID: 16697411 |
| Gene_locus related to this paper: bacsu-FENB |
| Title : Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain - Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
| Author(s) : Chakravarty B , Gu Z , Chirala SS , Wakil SJ , Quiocho FA |
| Ref : Proc Natl Acad Sci U S A , 101 :15567 , 2004 |
| Abstract : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
| ESTHER : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
| PubMedSearch : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
| PubMedID: 15507492 |
| Gene_locus related to this paper: human-FASN |
| Title : Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. - Bruner_2002_Structure_10_301 |
| Author(s) : Bruner SD , Weber T , Kohli RM , Schwarzer D , Marahiel MA , Walsh CT , Stubbs MT |
| Ref : Structure , 10 :301 , 2002 |
| Abstract : Bruner_2002_Structure_10_301 |
| ESTHER : Bruner_2002_Structure_10_301 |
| PubMedSearch : Bruner_2002_Structure_10_301 |
| PubMedID: 12005429 |
| Gene_locus related to this paper: bacsu-srfac |
| Title : Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases - Tsai_2002_Biochemistry_41_12598 |
| Author(s) : Tsai SC , Lu H , Cane DE , Khosla C , Stroud RM |
| Ref : Biochemistry , 41 :12598 , 2002 |
| Abstract : Tsai_2002_Biochemistry_41_12598 |
| ESTHER : Tsai_2002_Biochemistry_41_12598 |
| PubMedSearch : Tsai_2002_Biochemistry_41_12598 |
| PubMedID: 12379102 |
| Gene_locus related to this paper: sacer-ery3 , strve-PIKAIV |
| Title : Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel - Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
| Author(s) : Tsai SC , Miercke LJ , Krucinski J , Gokhale R , Chen JC , Foster PG , Cane DE , Khosla C , Stroud RM |
| Ref : Proc Natl Acad Sci U S A , 98 :14808 , 2001 |
| Abstract : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
| ESTHER : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
| PubMedSearch : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
| PubMedID: 11752428 |
| Gene_locus related to this paper: sacer-ery3 |
| Title : Fatty acid synthesis: a potential selective target for antineoplastic therapy. - |
| Author(s) : Kuhajda FP , Jenner K , Wood FD , Hennigar RA , Jacobs LB , Dick JD , Pasternack GR |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :6379 , 1994 |
| PubMedID: 8022791 |
| Gene_locus related to this paper: human-FASN |
Structures (84)
Genes Proteins in Thioesterase family (629)
Fragments of genes in Thioesterase family (27)
Structures in Thioesterase family (84)Substrates in Thioesterase family (9)
Inhibitors in Thioesterase family (29)