T6SS-TLE1
Comment
The type VI lipase effectors Tle1-Tle5 secreted by the bacterial type VI secretion system (T6SS) have recently been identified as antibacterial effectors that hydrolyze membrane phospholipids. The Tle1-4 display phospholipase A1 and A2 (PLA1) (PLA2) activities. Tle1 belongs to Duf_2235 (T6SS-TLE1) family, TLE2 to Lipase_3, TLE3 to alpha/ beta hydrolase(now the family (T6SS-TLE3) and Tle4 belongs to PGAP1. The adjacent genes code for VgrG proteins and putative periplasmic immunity proteins Tle5 are unrelated phospholipase D type. The bacterial type VI secretion system (T6SS) is a macromolecular machine that injects effectors into prokaryotic and eukaryotic cells. In enteroaggregative Escherichia coli, the Tle1 phospholipase binds the C-terminal extension of the VgrG trimeric spike. The inhibition of Tle1 phospholipase activity once bound to VgrG suggests that Tle1 dissociation from VgrG is required upon deliveryDatabase
Interpro : IPR018712 Protein of unknown function DUF2235
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF09994 DUF2235
Prints : No Print
EC Number : No EC Number
References (4)
| Title : The phospholipase effector Tle1(Vc) promotes Vibrio cholerae virulence by killing competitors and impacting gene expression - Liu_2023_Gut.Microbes_15_2241204 |
| Author(s) : Liu M , Wang H , Liu Y , Tian M , Wang Z , Shu RD , Zhao MY , Chen WD , Fu Y |
| Ref : Gut Microbes , 15 :2241204 , 2023 |
| Abstract : Liu_2023_Gut.Microbes_15_2241204 |
| ESTHER : Liu_2023_Gut.Microbes_15_2241204 |
| PubMedSearch : Liu_2023_Gut.Microbes_15_2241204 |
| PubMedID: 37526354 |
| Title : Structural basis for loading and inhibition of a bacterial T6SS phospholipase effector by the VgrG spike - Flaugnatti_2020_EMBO.J_39_e104129 |
| Author(s) : Flaugnatti N , Rapisarda C , Rey M , Beauvois SG , Nguyen VA , Canaan S , Durand E , Chamot-Rooke J , Cascales E , Fronzes R , Journet L |
| Ref : EMBO Journal , 39 :e104129 , 2020 |
| Abstract : Flaugnatti_2020_EMBO.J_39_e104129 |
| ESTHER : Flaugnatti_2020_EMBO.J_39_e104129 |
| PubMedSearch : Flaugnatti_2020_EMBO.J_39_e104129 |
| PubMedID: 32350888 |
| Gene_locus related to this paper: ecolx-h4unx0 |
| Title : Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting - Hu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_2175 |
| Author(s) : Hu H , Zhang H , Gao Z , Wang D , Liu G , Xu J , Lan K , Dong Y |
| Ref : Acta Crystallographica D Biol Crystallogr , 70 :2175 , 2014 |
| Abstract : Hu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_2175 |
| ESTHER : Hu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_2175 |
| PubMedSearch : Hu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_2175 |
| PubMedID: 25084336 |
| Gene_locus related to this paper: pseae-q9hyv3 |
| Title : Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors - Russell_2013_Nature_496_508 |
| Author(s) : Russell AB , LeRoux M , Hathazi K , Agnello DM , Ishikawa T , Wiggins PA , Wai SN , Mougous JD |
| Ref : Nature , 496 :508 , 2013 |
| Abstract : Russell_2013_Nature_496_508 |
| ESTHER : Russell_2013_Nature_496_508 |
| PubMedSearch : Russell_2013_Nature_496_508 |
| PubMedID: 23552891 |
| Gene_locus related to this paper: ecoli-T6SS.TLE3 |
Structures (3)
Genes Proteins in T6SS-TLE1 family (33)
Fragments of genes in T6SS-TLE1 family (1)
Structures in T6SS-TLE1 family (3)Substrates in T6SS-TLE1 family (1)
No Inhibitor