Neuroligin
Relationship
Comment
Neuroligins constitute a family of proteins thought to mediate cell-to-cell interactions between neurons. Neuroligins function as ligands for the neurexin family and MADD-4. This interaction is necessary for GABA receptors clustering. Mammals have four Nlgn proteins, with the Nlgn3 and Nlgn4 gene in humans localised to the X-chromosome. In humans, the Nlgn4 gene is complemented on the Y-chromosome by a similar Nlgn4Y gene.(from OMIM) In 2 brothers with autism, one with typical autism and the other with Asperger syndrome, Jamain et al. (2003) identified a frameshift mutation (1186T) in the human-NLGN4X gene, resulting in a stop codon at position 396 and premature truncation of the protein before the transmembrane domain. The mutation was present in the mother and absent in an unaffected brother and 350 controls. See other contradictory results Gauthier et al. Vincent et al., but other mutations found Laumonnier et al. Yan et al. Incomplete penetrance suspected for some mutations. In 2 brothers with autism, one with typical autism and the other with Asperger syndrome, Jamain et al. (2003) identified a mutation R451C in the human-NLGN3 gene. arg451 in NLGN3, arg386 in BCHE, and arg395 in ACHE are conserved in mammalian species.
In cellular transfection studies, De Jaco et al. (2006) inserted mutations homologous to the NLGN3 R451C mutation in BCHE and ACHE cDNAs and found that these mutations resulted in endoplasmic reticulum retention of the 2 proteins, similar to that observed with the NLGN3 R451C mutant protein. Tabuchi et al. (2007) introduced the R451C substitution in neuroligin-3 into mice. R451C mutant mice showed impaired social interactions but enhanced spatial learning abilities. Unexpectedly these behavioral changes were accompanied by an increase in inhibitory synaptic transmission with no apparent effect on excitatory synapses. Deletion of neuroligin-3, in contrast, did not cause such changes, indicating that the R451C substitution represents a gain-of-function mutation. Tabuchi et al. (2007) concluded that increased inhibitory synaptic transmission may contribute to human autism spectrum disorders and that the R451C knockin mice may be a useful model for studying autism-related behaviors. Recently Venkatesh et al. showed that neuronal activity promotes glioma growth through Neuroligin-3 secretion. Recently Neuroligin 2 mutations were associated with anxiety, autism, intellectual disability, hyperphagia, and obesity.Many mutations on X-linked cell NLGN4X result in ASD or intellectual disability. NLGN4Y cannot compensate for the functional deficits due to NLGN4X mutations (obsolete entries: Interpro IPR030022 Neuroligin-1, IPR030023 Neuroligin-2, IPR030024 Neuroligin-3 IPR030025 Neuroligin-4) Database
Interpro : IPR000460 Neuroligin , IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : No Pdoc
Pfam : PF00135 COesterase
Prints : No Print
EC Number : No EC Number
References (73)
| Title : Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin - Cowen_2024_iScience_27_109477 |
| Author(s) : Cowen MH , Raizen DM , Hart MP |
| Ref : iScience , 27 :109477 , 2024 |
| Abstract : Cowen_2024_iScience_27_109477 |
| ESTHER : Cowen_2024_iScience_27_109477 |
| PubMedSearch : Cowen_2024_iScience_27_109477 |
| PubMedID: 38551003 |
| Title : Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice - Leduc_2024_Mol.Autism_15_13 |
| Author(s) : Leduc T , El Alami H , Bougadir K , Belanger-Nelson E , Mongrain V |
| Ref : Mol Autism , 15 :13 , 2024 |
| Abstract : Leduc_2024_Mol.Autism_15_13 |
| ESTHER : Leduc_2024_Mol.Autism_15_13 |
| PubMedSearch : Leduc_2024_Mol.Autism_15_13 |
| PubMedID: 38570872 |
| Gene_locus related to this paper: human-NLGN2 , mouse-2neur |
| Title : Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task - Li_2024_Psychopharmacology.(Berl)__ |
| Author(s) : Li S , May C , Pang TY , Churilov L , Hannan AJ , Johnson KA , Burrows EL |
| Ref : Psychopharmacology (Berl) , : , 2024 |
| Abstract : Li_2024_Psychopharmacology.(Berl)__ |
| ESTHER : Li_2024_Psychopharmacology.(Berl)__ |
| PubMedSearch : Li_2024_Psychopharmacology.(Berl)__ |
| PubMedID: 38170320 |
| Gene_locus related to this paper: human-NLGN3 , mouse-3neur |
| Title : Engineered adhesion molecules drive synapse organization - Hale_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2215905120 |
| Author(s) : Hale WD , Sudhof TC , Huganir RL |
| Ref : Proc Natl Acad Sci U S A , 120 :e2215905120 , 2023 |
| Abstract : Hale_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2215905120 |
| ESTHER : Hale_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2215905120 |
| PubMedSearch : Hale_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2215905120 |
| PubMedID: 36638214 |
| Title : Multiple N-linked glycosylation sites critically modulate the synaptic abundance of Neuroligin isoforms - Benner_2023_J.Biol.Chem__105361 |
| Author(s) : Benner O , Cast TP , Minamide LS , Lenninger Z , Bamburg JR , Chanda S |
| Ref : Journal of Biological Chemistry , :105361 , 2023 |
| Abstract : Benner_2023_J.Biol.Chem__105361 |
| ESTHER : Benner_2023_J.Biol.Chem__105361 |
| PubMedSearch : Benner_2023_J.Biol.Chem__105361 |
| PubMedID: 37865312 |
| Title : Targeting Wnt\/beta-catenin-mediated upregulation of oncogenic NLGN3 suppresses cancer stem cells in glioblastoma - Yun_2023_Cell.Death.Dis_14_423 |
| Author(s) : Yun EJ , Kim D , Kim S , Hsieh JT , Baek ST |
| Ref : Cell Death Dis , 14 :423 , 2023 |
| Abstract : Yun_2023_Cell.Death.Dis_14_423 |
| ESTHER : Yun_2023_Cell.Death.Dis_14_423 |
| PubMedSearch : Yun_2023_Cell.Death.Dis_14_423 |
| PubMedID: 37443071 |
| Title : Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses - Altas_2023_Biol.Psychiatry__ |
| Author(s) : Altas B , Tuffy LP , Patrizi A , Dimova K , Soykan T , Brandenburg C , Romanowski AJ , Whitten JR , Robertson CD , Khim SN , Crutcher GW , Ambrozkiewicz MC , Yagensky O , Krueger-Burg D , Hammer M , Hsiao HH , Laskowski PR , Dyck L , Puche AC , Sassoe-Pognetto M , Chua JJE , Urlaub H , Jahn O , Brose N , Poulopoulos A |
| Ref : Biological Psychiatryry , : , 2023 |
| Abstract : Altas_2023_Biol.Psychiatry__ |
| ESTHER : Altas_2023_Biol.Psychiatry__ |
| PubMedSearch : Altas_2023_Biol.Psychiatry__ |
| PubMedID: 38154503 |
| Gene_locus related to this paper: human-NLGN3 , mouse-3neur |
| Title : Expression alteration of Neuroligin family gene in attention deficit and hyperactivity disorder and autism spectrum disorder - Bay_2023_Res.Dev.Disabil_139_104558 |
| Author(s) : Bay H , Haghighatfard A , Karimipour M , Seyedena SY , Hashemi M |
| Ref : Res Dev Disabil , 139 :104558 , 2023 |
| Abstract : Bay_2023_Res.Dev.Disabil_139_104558 |
| ESTHER : Bay_2023_Res.Dev.Disabil_139_104558 |
| PubMedSearch : Bay_2023_Res.Dev.Disabil_139_104558 |
| PubMedID: 37285744 |
| Title : NLGN4X TCR transgenic T cells to treat gliomas - Kramer_2023_Neuro.Oncol__ |
| Author(s) : Kramer C , Kilian M , Chih YC , Kourtesakis A , Hoffmann DC , Boschert T , Koopmann P , Sanghvi K , De Roia A , Jung S , Jahne K , Day B , Shultz LD , Ratliff M , Harbottle R , Green EW , Will R , Wick W , Platten M , Bunse L |
| Ref : Neuro Oncol , : , 2023 |
| Abstract : Kramer_2023_Neuro.Oncol__ |
| ESTHER : Kramer_2023_Neuro.Oncol__ |
| PubMedSearch : Kramer_2023_Neuro.Oncol__ |
| PubMedID: 37715782 |
| Gene_locus related to this paper: human-NLGN4X , mouse-4neur |
| Title : Of Humans and Gerbils- Independent Diversification of Neuroligin-4 Into X- and Y-Specific Genes in Primates and Rodents - Maxeiner_2022_Front.Mol.Neurosci_15_838262 |
| Author(s) : Maxeiner S , Benseler F , Brose N , Krasteva-Christ G |
| Ref : Front Mol Neurosci , 15 :838262 , 2022 |
| Abstract : Maxeiner_2022_Front.Mol.Neurosci_15_838262 |
| ESTHER : Maxeiner_2022_Front.Mol.Neurosci_15_838262 |
| PubMedSearch : Maxeiner_2022_Front.Mol.Neurosci_15_838262 |
| PubMedID: 35431802 |
| Title : Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3 - Ramirez_2022_iScience_25_104803 |
| Author(s) : Ramirez MA , Ninoyu Y , Miller C , Andrade LR , Edassery S , Bomba-Warczak E , Ortega B , Manor U , Rutherford MA , Friedman RA , Savas JN |
| Ref : iScience , 25 :104803 , 2022 |
| Abstract : Ramirez_2022_iScience_25_104803 |
| ESTHER : Ramirez_2022_iScience_25_104803 |
| PubMedSearch : Ramirez_2022_iScience_25_104803 |
| PubMedID: 35992071 |
| Title : The neuroligins and the synaptic pathway in Autism Spectrum Disorder - Trobiani_2020_Neurosci.Biobehav.Rev_119_37 |
| Author(s) : Trobiani L , Meringolo M , Diamanti T , Bourne Y , Marchot P , Martella G , Dini L , Pisani A , De Jaco A , Bonsi P |
| Ref : Neurosci Biobehav Rev , 119 :37 , 2020 |
| Abstract : Trobiani_2020_Neurosci.Biobehav.Rev_119_37 |
| ESTHER : Trobiani_2020_Neurosci.Biobehav.Rev_119_37 |
| PubMedSearch : Trobiani_2020_Neurosci.Biobehav.Rev_119_37 |
| PubMedID: 32991906 |
| Title : A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y - Nguyen_2020_Neuron_106_759 |
| Author(s) : Nguyen TA , Wu K , Pandey S , Lehr AW , Li Y , Bemben MA , Badger JD, 2nd , Lauzon JL , Wang T , Zaghloul KA , Thurm A , Jain M , Lu W , Roche KW |
| Ref : Neuron , 106 :759 , 2020 |
| Abstract : Nguyen_2020_Neuron_106_759 |
| ESTHER : Nguyen_2020_Neuron_106_759 |
| PubMedSearch : Nguyen_2020_Neuron_106_759 |
| PubMedID: 32243781 |
| Gene_locus related to this paper: human-NLGN4X |
| Title : Neuroligin 2 nonsense variant associated with anxiety, autism, intellectual disability, hyperphagia, and obesity - Parente_2017_Am.J.Med.Genet.A_173_213 |
| Author(s) : Parente DJ , Garriga C , Baskin B , Douglas G , Cho MT , Araujo GC , Shinawi M |
| Ref : American Journal of Medicine Genet A , 173 :213 , 2017 |
| Abstract : Parente_2017_Am.J.Med.Genet.A_173_213 |
| ESTHER : Parente_2017_Am.J.Med.Genet.A_173_213 |
| PubMedSearch : Parente_2017_Am.J.Med.Genet.A_173_213 |
| PubMedID: 27865048 |
| Gene_locus related to this paper: human-NLGN2 |
| Title : C. elegans Punctin Clusters GABA Receptors via Neuroligin Binding and UNC-40\/DCC Recruitment - Tu_2015_Neuron_86_1407 |
| Author(s) : Tu H , Pinan-Lucarre B , Ji T , Jospin M , Bessereau JL |
| Ref : Neuron , 86 :1407 , 2015 |
| Abstract : Tu_2015_Neuron_86_1407 |
| ESTHER : Tu_2015_Neuron_86_1407 |
| PubMedSearch : Tu_2015_Neuron_86_1407 |
| PubMedID: 26028575 |
| Gene_locus related to this paper: caeel-NLGN1 |
| Title : MADD-4\/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin - Maro_2015_Neuron_86_1420 |
| Author(s) : Maro GS , Gao S , Olechwier AM , Hung WL , Liu M , Ozkan E , Zhen M , Shen K |
| Ref : Neuron , 86 :1420 , 2015 |
| Abstract : Maro_2015_Neuron_86_1420 |
| ESTHER : Maro_2015_Neuron_86_1420 |
| PubMedSearch : Maro_2015_Neuron_86_1420 |
| PubMedID: 26028574 |
| Gene_locus related to this paper: caeel-NLGN1 |
| Title : Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion - Venkatesh_2015_Cell_161_803 |
| Author(s) : Venkatesh HS , Johung TB , Caretti V , Noll A , Tang Y , Nagaraja S , Gibson EM , Mount CW , Polepalli J , Mitra SS , Woo PJ , Malenka RC , Vogel H , Bredel M , Mallick P , Monje M |
| Ref : Cell , 161 :803 , 2015 |
| Abstract : Venkatesh_2015_Cell_161_803 |
| ESTHER : Venkatesh_2015_Cell_161_803 |
| PubMedSearch : Venkatesh_2015_Cell_161_803 |
| PubMedID: 25913192 |
| Gene_locus related to this paper: human-NLGN3 |
| Title : Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins - Lenfant_2014_J.Mol.Neurosci_53_362 |
| Author(s) : Lenfant N , Hotelier T , Bourne Y , Marchot P , Chatonnet A |
| Ref : Journal of Molecular Neuroscience , 53 :362 , 2014 |
| Abstract : Lenfant_2014_J.Mol.Neurosci_53_362 |
| ESTHER : Lenfant_2014_J.Mol.Neurosci_53_362 |
| PubMedSearch : Lenfant_2014_J.Mol.Neurosci_53_362 |
| PubMedID: 24390353 |
| Title : Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia - Sun_2011_Hum.Mol.Genet_20_3042 |
| Author(s) : Sun C , Cheng MC , Qin R , Liao DL , Chen TT , Koong FJ , Chen G , Chen CH |
| Ref : Hum Mol Genet , 20 :3042 , 2011 |
| Abstract : Sun_2011_Hum.Mol.Genet_20_3042 |
| ESTHER : Sun_2011_Hum.Mol.Genet_20_3042 |
| PubMedSearch : Sun_2011_Hum.Mol.Genet_20_3042 |
| PubMedID: 21551456 |
| Gene_locus related to this paper: human-NLGN2 |
| Title : Beyond the random coil: stochastic conformational switching in intrinsically disordered proteins - Choi_2011_Structure_19_566 |
| Author(s) : Choi UB , McCann JJ , Weninger KR , Bowen ME |
| Ref : Structure , 19 :566 , 2011 |
| Abstract : Choi_2011_Structure_19_566 |
| ESTHER : Choi_2011_Structure_19_566 |
| PubMedSearch : Choi_2011_Structure_19_566 |
| PubMedID: 21481779 |
| Title : Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses - Budreck_2007_Eur.J.Neurosci_26_1738 |
| Author(s) : Budreck EC , Scheiffele P |
| Ref : European Journal of Neuroscience , 26 :1738 , 2007 |
| Abstract : Budreck_2007_Eur.J.Neurosci_26_1738 |
| ESTHER : Budreck_2007_Eur.J.Neurosci_26_1738 |
| PubMedSearch : Budreck_2007_Eur.J.Neurosci_26_1738 |
| PubMedID: 17897391 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : Adhesion molecules in the nervous system: structural insights into function and diversity - Shapiro_2007_Annu.Rev.Neurosci_30_451 |
| Author(s) : Shapiro L , Love J , Colman DR |
| Ref : Annual Review of Neuroscience , 30 :451 , 2007 |
| Abstract : Shapiro_2007_Annu.Rev.Neurosci_30_451 |
| ESTHER : Shapiro_2007_Annu.Rev.Neurosci_30_451 |
| PubMedSearch : Shapiro_2007_Annu.Rev.Neurosci_30_451 |
| PubMedID: 17600523 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations - Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41 |
| Author(s) : Yamakawa H , Oyama S , Mitsuhashi H , Sasagawa N , Uchino S , Kohsaka S , Ishiura S |
| Ref : Biochemical & Biophysical Research Communications , 355 :41 , 2007 |
| Abstract : Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41 |
| ESTHER : Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41 |
| PubMedSearch : Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41 |
| PubMedID: 17292328 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : Neuroscience. Autism's cause may reside in abnormalities at the synapse - |
| Author(s) : Garber K |
| Ref : Science , 317 :190 , 2007 |
| PubMedID: 17626859 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : Synaptic arrangement of the neuroligin\/beta-neurexin complex revealed by X-ray and neutron scattering - Comoletti_2007_Structure_15_693 |
| Author(s) : Comoletti D , Grishaev A , Whitten AE , Tsigelny I , Taylor P , Trewhella J |
| Ref : Structure , 15 :693 , 2007 |
| Abstract : Comoletti_2007_Structure_15_693 |
| ESTHER : Comoletti_2007_Structure_15_693 |
| PubMedSearch : Comoletti_2007_Structure_15_693 |
| PubMedID: 17562316 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice - Tabuchi_2007_Science_318_71 |
| Author(s) : Tabuchi K , Blundell J , Etherton MR , Hammer RE , Liu X , Powell CM , Sudhof TC |
| Ref : Science , 318 :71 , 2007 |
| Abstract : Tabuchi_2007_Science_318_71 |
| ESTHER : Tabuchi_2007_Science_318_71 |
| PubMedSearch : Tabuchi_2007_Science_318_71 |
| PubMedID: 17823315 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : Neurexin-neuroligin signaling in synapse development - Craig_2007_Curr.Opin.Neurobiol_17_43 |
| Author(s) : Craig AM , Kang Y |
| Ref : Current Opinion in Neurobiology , 17 :43 , 2007 |
| Abstract : Craig_2007_Curr.Opin.Neurobiol_17_43 |
| ESTHER : Craig_2007_Curr.Opin.Neurobiol_17_43 |
| PubMedSearch : Craig_2007_Curr.Opin.Neurobiol_17_43 |
| PubMedID: 17275284 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : Medicine. Testing hypotheses about autism - |
| Author(s) : Crawley JN |
| Ref : Science , 318 :56 , 2007 |
| PubMedID: 17916718 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses - Berninghausen_2007_J.Neurochem_103_1855 |
| Author(s) : Berninghausen O , Rahman MA , Silva JP , Davletov B , Hopkins C , Ushkaryov YA |
| Ref : Journal of Neurochemistry , 103 :1855 , 2007 |
| Abstract : Berninghausen_2007_J.Neurochem_103_1855 |
| ESTHER : Berninghausen_2007_J.Neurochem_103_1855 |
| PubMedSearch : Berninghausen_2007_J.Neurochem_103_1855 |
| PubMedID: 17868325 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : NLGN3\/NLGN4 gene mutations are not responsible for autism in the Quebec population - Gauthier_2005_Am.J.Med.Genet.B.Neuropsychiatr.Genet_132B_74 |
| Author(s) : Gauthier J , Bonnel A , St-Onge J , Karemera L , Laurent S , Mottron L , Fombonne E , Joober R , Rouleau GA |
| Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 132B :74 , 2005 |
| Abstract : Gauthier_2005_Am.J.Med.Genet.B.Neuropsychiatr.Genet_132B_74 |
| ESTHER : Gauthier_2005_Am.J.Med.Genet.B.Neuropsychiatr.Genet_132B_74 |
| PubMedSearch : Gauthier_2005_Am.J.Med.Genet.B.Neuropsychiatr.Genet_132B_74 |
| PubMedID: 15389766 |
| Gene_locus related to this paper: human-NLGN4X |
| Title : Analysis of four neuroligin genes as candidates for autism - Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285 |
| Author(s) : Ylisaukko-oja T , Rehnstrom K , Auranen M , Vanhala R , Alen R , Kempas E , Ellonen P , Turunen JA , Makkonen I , Riikonen R , Nieminen-von Wendt T , von Wendt L , Peltonen L , Jarvela I |
| Ref : Eur J Hum Genet , 13 :1285 , 2005 |
| Abstract : Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285 |
| ESTHER : Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285 |
| PubMedSearch : Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285 |
| PubMedID: 16077734 |
| Gene_locus related to this paper: human-NLGN4Y , human-NLGN1 , human-NLGN3 , human-NLGN4X |
| Title : Control of excitatory and inhibitory synapse formation by neuroligins - Chih_2005_Science_307_1324 |
| Author(s) : Chih B , Engelman H , Scheiffele P |
| Ref : Science , 307 :1324 , 2005 |
| Abstract : Chih_2005_Science_307_1324 |
| ESTHER : Chih_2005_Science_307_1324 |
| PubMedSearch : Chih_2005_Science_307_1324 |
| PubMedID: 15681343 |
| Title : Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients - |
| Author(s) : Yan J , Oliveira G , Coutinho A , Yang C , Feng J , Katz C , Sram J , Bockholt A , Jones IR , Craddock N , Cook EH, Jr. , Vicente A , Sommer SS |
| Ref : Mol Psychiatry , 10 :329 , 2005 |
| PubMedID: 15622415 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
| Title : Selective capability of SynCAM and neuroligin for functional synapse assembly - Sara_2005_J.Neurosci_25_260 |
| Author(s) : Sara Y , Biederer T , Atasoy D , Chubykin AA , Mozhayeva MG , Sudhof TC , Kavalali ET |
| Ref : Journal of Neuroscience , 25 :260 , 2005 |
| Abstract : Sara_2005_J.Neurosci_25_260 |
| ESTHER : Sara_2005_J.Neurosci_25_260 |
| PubMedSearch : Sara_2005_J.Neurosci_25_260 |
| PubMedID: 15634790 |
| Title : Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity - Levinson_2005_J.Biol.Chem_280_17312 |
| Author(s) : Levinson JN , Chery N , Huang K , Wong TP , Gerrow K , Kang R , Prange O , Wang YT , El-Husseini A |
| Ref : Journal of Biological Chemistry , 280 :17312 , 2005 |
| Abstract : Levinson_2005_J.Biol.Chem_280_17312 |
| ESTHER : Levinson_2005_J.Biol.Chem_280_17312 |
| PubMedSearch : Levinson_2005_J.Biol.Chem_280_17312 |
| PubMedID: 15723836 |
| Title : Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands - Vincent_2004_Am.J.Med.Genet.B.Neuropsychiatr.Genet_129B_82 |
| Author(s) : Vincent JB , Kolozsvari D , Roberts WS , Bolton PF , Gurling HM , Scherer SW |
| Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 129B :82 , 2004 |
| Abstract : Vincent_2004_Am.J.Med.Genet.B.Neuropsychiatr.Genet_129B_82 |
| ESTHER : Vincent_2004_Am.J.Med.Genet.B.Neuropsychiatr.Genet_129B_82 |
| PubMedSearch : Vincent_2004_Am.J.Med.Genet.B.Neuropsychiatr.Genet_129B_82 |
| PubMedID: 15274046 |
| Title : Synaptic scaffolding molecule interacts with axin - Hirabayashi_2004_J.Neurochem_90_332 |
| Author(s) : Hirabayashi S , Nishimura W , Iida J , Kansaku A , Kishida S , Kikuchi A , Tanaka N , Hata Y |
| Ref : Journal of Neurochemistry , 90 :332 , 2004 |
| Abstract : Hirabayashi_2004_J.Neurochem_90_332 |
| ESTHER : Hirabayashi_2004_J.Neurochem_90_332 |
| PubMedSearch : Hirabayashi_2004_J.Neurochem_90_332 |
| PubMedID: 15228590 |
| Title : Disorder-associated mutations lead to functional inactivation of neuroligins - Chih_2004_Hum.Mol.Genet_13_1471 |
| Author(s) : Chih B , Afridi SK , Clark L , Scheiffele P |
| Ref : Hum Mol Genet , 13 :1471 , 2004 |
| Abstract : Chih_2004_Hum.Mol.Genet_13_1471 |
| ESTHER : Chih_2004_Hum.Mol.Genet_13_1471 |
| PubMedSearch : Chih_2004_Hum.Mol.Genet_13_1471 |
| PubMedID: 15150161 |
| Title : Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons - Dong_2004_J.Neurosci_24_8950 |
| Author(s) : Dong H , Xiang YY , Farchi N , Ju W , Wu Y , Chen L , Wang Y , Hochner B , Yang B , Soreq H , Lu WY |
| Ref : Journal of Neuroscience , 24 :8950 , 2004 |
| Abstract : Dong_2004_J.Neurosci_24_8950 |
| ESTHER : Dong_2004_J.Neurosci_24_8950 |
| PubMedSearch : Dong_2004_J.Neurosci_24_8950 |
| PubMedID: 15483114 |
| Title : Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry - Hoffman_2004_Biochemistry_43_1496 |
| Author(s) : Hoffman RC , Jennings LL , Tsigelny I , Comoletti D , Flynn RE , Sudhof TC , Taylor P |
| Ref : Biochemistry , 43 :1496 , 2004 |
| Abstract : Hoffman_2004_Biochemistry_43_1496 |
| ESTHER : Hoffman_2004_Biochemistry_43_1496 |
| PubMedSearch : Hoffman_2004_Biochemistry_43_1496 |
| PubMedID: 14769026 |
| Gene_locus related to this paper: ratno-1neur |
| Title : The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin - Meyer_2004_Neuropharmacol_47_724 |
| Author(s) : Meyer G , Varoqueaux F , Neeb A , Oschlies M , Brose N |
| Ref : Neuropharmacology , 47 :724 , 2004 |
| Abstract : Meyer_2004_Neuropharmacol_47_724 |
| ESTHER : Meyer_2004_Neuropharmacol_47_724 |
| PubMedSearch : Meyer_2004_Neuropharmacol_47_724 |
| PubMedID: 15458844 |
| Gene_locus related to this paper: ratno-1neur |
| Title : Do known mutations in neuroligin genes (NLGN3 and NLGN4) cause autism? - |
| Author(s) : Talebizadeh Z , Bittel DC , Veatch OJ , Butler MG , Takahashi TN , Miles JH |
| Ref : J Autism Dev Disord , 34 :735 , 2004 |
| PubMedID: 15679194 |
| Title : Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins - Graf_2004_Cell_119_1013 |
| Author(s) : Graf ER , Zhang X , Jin SX , Linhoff MW , Craig AM |
| Ref : Cell , 119 :1013 , 2004 |
| Abstract : Graf_2004_Cell_119_1013 |
| ESTHER : Graf_2004_Cell_119_1013 |
| PubMedSearch : Graf_2004_Cell_119_1013 |
| PubMedID: 15620359 |
| Title : The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing - Comoletti_2004_J.Neurosci_24_4889 |
| Author(s) : Comoletti D , De Jaco A , Jennings LL , Flynn RE , Gaietta G , Tsigelny I , Ellisman MH , Taylor P |
| Ref : Journal of Neuroscience , 24 :4889 , 2004 |
| Abstract : Comoletti_2004_J.Neurosci_24_4889 |
| ESTHER : Comoletti_2004_J.Neurosci_24_4889 |
| PubMedSearch : Comoletti_2004_J.Neurosci_24_4889 |
| PubMedID: 15152050 |
| Title : Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin - Iida_2004_Mol.Cell.Neurosci_27_497 |
| Author(s) : Iida J , Hirabayashi S , Sato Y , Hata Y |
| Ref : Molecular & Cellular Neurosciences , 27 :497 , 2004 |
| Abstract : Iida_2004_Mol.Cell.Neurosci_27_497 |
| ESTHER : Iida_2004_Mol.Cell.Neurosci_27_497 |
| PubMedSearch : Iida_2004_Mol.Cell.Neurosci_27_497 |
| PubMedID: 15555927 |
| Title : Synaptic targeting of neuroligin is independent of neurexin and SAP90\/PSD95 binding - Dresbach_2004_Mol.Cell.Neurosci_27_227 |
| Author(s) : Dresbach T , Neeb A , Meyer G , Gundelfinger ED , Brose N |
| Ref : Molecular & Cellular Neurosciences , 27 :227 , 2004 |
| Abstract : Dresbach_2004_Mol.Cell.Neurosci_27_227 |
| ESTHER : Dresbach_2004_Mol.Cell.Neurosci_27_227 |
| PubMedSearch : Dresbach_2004_Mol.Cell.Neurosci_27_227 |
| PubMedID: 15519238 |
| Title : X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family - Laumonnier_2004_Am.J.Hum.Genet_74_552 |
| Author(s) : Laumonnier F , Bonnet-Brilhault F , Gomot M , Blanc R , David A , Moizard MP , Raynaud M , Ronce N , Lemonnier E , Calvas P , Laudier B , Chelly J , Fryns JP , Ropers HH , Hamel BC , Andres C , Barthelemy C , Moraine C , Briault S |
| Ref : American Journal of Human Genetics , 74 :552 , 2004 |
| Abstract : Laumonnier_2004_Am.J.Hum.Genet_74_552 |
| ESTHER : Laumonnier_2004_Am.J.Hum.Genet_74_552 |
| PubMedSearch : Laumonnier_2004_Am.J.Hum.Genet_74_552 |
| PubMedID: 14963808 |
| Gene_locus related to this paper: human-NLGN4X |
| Title : A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin - Prange_2004_Proc.Natl.Acad.Sci.U.S.A_101_13915 |
| Author(s) : Prange O , Wong TP , Gerrow K , Wang YT , El-Husseini A |
| Ref : Proc Natl Acad Sci U S A , 101 :13915 , 2004 |
| Abstract : Prange_2004_Proc.Natl.Acad.Sci.U.S.A_101_13915 |
| ESTHER : Prange_2004_Proc.Natl.Acad.Sci.U.S.A_101_13915 |
| PubMedSearch : Prange_2004_Proc.Natl.Acad.Sci.U.S.A_101_13915 |
| PubMedID: 15358863 |
| Title : Neuroligin 2 is exclusively localized to inhibitory synapses - Varoqueaux_2004_Eur.J.Cell.Biol_83_449 |
| Author(s) : Varoqueaux F , Jamain S , Brose N |
| Ref : European Journal of Cell Biology , 83 :449 , 2004 |
| Abstract : Varoqueaux_2004_Eur.J.Cell.Biol_83_449 |
| ESTHER : Varoqueaux_2004_Eur.J.Cell.Biol_83_449 |
| PubMedSearch : Varoqueaux_2004_Eur.J.Cell.Biol_83_449 |
| PubMedID: 15540461 |
| Title : Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors - Fu_2003_J.Neurophysiol_90_3950 |
| Author(s) : Fu Z , Washbourne P , Ortinski P , Vicini S |
| Ref : Journal of Neurophysiology , 90 :3950 , 2003 |
| Abstract : Fu_2003_J.Neurophysiol_90_3950 |
| ESTHER : Fu_2003_J.Neurophysiol_90_3950 |
| PubMedSearch : Fu_2003_J.Neurophysiol_90_3950 |
| PubMedID: 12930820 |
| Title : Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta - Comoletti_2003_J.Biol.Chem_278_50497 |
| Author(s) : Comoletti D , Flynn RE , Jennings LL , Chubykin AA , Matsumura T , Hasegawa H , Sudhof TC , Taylor P |
| Ref : Journal of Biological Chemistry , 278 :50497 , 2003 |
| Abstract : Comoletti_2003_J.Biol.Chem_278_50497 |
| ESTHER : Comoletti_2003_J.Biol.Chem_278_50497 |
| PubMedSearch : Comoletti_2003_J.Biol.Chem_278_50497 |
| PubMedID: 14522992 |
| Title : Synaptic adhesion molecules - Yamagata_2003_Curr.Opin.Cell.Biol_15_621 |
| Author(s) : Yamagata M , Sanes JR , Weiner JA |
| Ref : Current Opinion in Cell Biology , 15 :621 , 2003 |
| Abstract : Yamagata_2003_Curr.Opin.Cell.Biol_15_621 |
| ESTHER : Yamagata_2003_Curr.Opin.Cell.Biol_15_621 |
| PubMedSearch : Yamagata_2003_Curr.Opin.Cell.Biol_15_621 |
| PubMedID: 14519398 |
| Title : Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism - Jamain_2003_Nat.Genet_34_27 |
| Author(s) : Jamain S , Quach H , Betancur C , Rastam M , Colineaux C , Gillberg IC , Soderstrom H , Giros B , Leboyer M , Gillberg C , Bourgeron T |
| Ref : Nat Genet , 34 :27 , 2003 |
| Abstract : Jamain_2003_Nat.Genet_34_27 |
| ESTHER : Jamain_2003_Nat.Genet_34_27 |
| PubMedSearch : Jamain_2003_Nat.Genet_34_27 |
| PubMedID: 12669065 |
| Gene_locus related to this paper: human-NLGN2 , human-NLGN4X , human-NLGN4Y , mouse-4neur , human-NLGN3 |
| Title : Neurexin mediates the assembly of presynaptic terminals - Dean_2003_Nat.Neurosci_6_708 |
| Author(s) : Dean C , Scholl FG , Choih J , DeMaria S , Berger J , Isacoff E , Scheiffele P |
| Ref : Nat Neurosci , 6 :708 , 2003 |
| Abstract : Dean_2003_Nat.Neurosci_6_708 |
| ESTHER : Dean_2003_Nat.Neurosci_6_708 |
| PubMedSearch : Dean_2003_Nat.Neurosci_6_708 |
| PubMedID: 12796785 |
| Title : Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb - Clarris_2002_Int.J.Dev.Biol_46_649 |
| Author(s) : Clarris HJ , McKeown S , Key B |
| Ref : Int J Developmental Biology , 46 :649 , 2002 |
| Abstract : Clarris_2002_Int.J.Dev.Biol_46_649 |
| ESTHER : Clarris_2002_Int.J.Dev.Biol_46_649 |
| PubMedSearch : Clarris_2002_Int.J.Dev.Biol_46_649 |
| PubMedID: 12141453 |
| Title : Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression - Bolliger_2001_Biochem.J_356_581 |
| Author(s) : Bolliger MF , Frei K , Winterhalter KH , Gloor SM |
| Ref : Biochemical Journal , 356 :581 , 2001 |
| Abstract : Bolliger_2001_Biochem.J_356_581 |
| ESTHER : Bolliger_2001_Biochem.J_356_581 |
| PubMedSearch : Bolliger_2001_Biochem.J_356_581 |
| PubMedID: 11368788 |
| Gene_locus related to this paper: human-NLGN4X |
| Title : A stoichiometric complex of neurexins and dystroglycan in brain - Sugita_2001_J.Cell.Biol_154_435 |
| Author(s) : Sugita S , Saito F , Tang J , Satz J , Campbell K , Sudhof TC |
| Ref : Journal of Cell Biology , 154 :435 , 2001 |
| Abstract : Sugita_2001_J.Cell.Biol_154_435 |
| ESTHER : Sugita_2001_J.Cell.Biol_154_435 |
| PubMedSearch : Sugita_2001_J.Cell.Biol_154_435 |
| PubMedID: 11470830 |
| Title : Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia - Gilbert_2001_Glia_34_151 |
| Author(s) : Gilbert M , Smith J , Roskams AJ , Auld VJ |
| Ref : Glia , 34 :151 , 2001 |
| Abstract : Gilbert_2001_Glia_34_151 |
| ESTHER : Gilbert_2001_Glia_34_151 |
| PubMedSearch : Gilbert_2001_Glia_34_151 |
| PubMedID: 11329178 |
| Gene_locus related to this paper: mouse-3neur , ratno-1neur , ratno-2neur , ratno-3neur |
| Title : Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations - Tsigelny_2000_Protein.Sci_9_180 |
| Author(s) : Tsigelny I , Shindyalov IN , Bourne PE , Sudhof TC , Taylor P |
| Ref : Protein Science , 9 :180 , 2000 |
| Abstract : Tsigelny_2000_Protein.Sci_9_180 |
| ESTHER : Tsigelny_2000_Protein.Sci_9_180 |
| PubMedSearch : Tsigelny_2000_Protein.Sci_9_180 |
| PubMedID: 10739260 |
| Title : Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons - Scheiffele_2000_Cell_101_657 |
| Author(s) : Scheiffele P , Fan J , Choih J , Fetter R , Serafini T |
| Ref : Cell , 101 :657 , 2000 |
| Abstract : Scheiffele_2000_Cell_101_657 |
| ESTHER : Scheiffele_2000_Cell_101_657 |
| PubMedSearch : Scheiffele_2000_Cell_101_657 |
| PubMedID: 10892652 |
| Gene_locus related to this paper: human-NLGN1 , human-NLGN2 |
| Title : Synapse formation: if it looks like a duck and quacks like a duck - Cantallops_2000_Curr.Biol_10_R620 |
| Author(s) : Cantallops I , Cline HT |
| Ref : Current Biology , 10 :R620 , 2000 |
| Abstract : Cantallops_2000_Curr.Biol_10_R620 |
| ESTHER : Cantallops_2000_Curr.Biol_10_R620 |
| PubMedSearch : Cantallops_2000_Curr.Biol_10_R620 |
| PubMedID: 10996085 |
| Title : The structure and expression of the human neuroligin-3 gene - Philibert_2000_Gene_246_303 |
| Author(s) : Philibert RA , Winfield SL , Sandhu HK , Martin BM , Ginns EI |
| Ref : Gene , 246 :303 , 2000 |
| Abstract : Philibert_2000_Gene_246_303 |
| ESTHER : Philibert_2000_Gene_246_303 |
| PubMedSearch : Philibert_2000_Gene_246_303 |
| PubMedID: 10767552 |
| Gene_locus related to this paper: human-NLGN3 |
| Title : Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses - Song_1999_Proc.Natl.Acad.Sci.U.S.A_96_1100 |
| Author(s) : Song JY , Ichtchenko K , Sudhof TC , Brose N |
| Ref : Proc Natl Acad Sci U S A , 96 :1100 , 1999 |
| Abstract : Song_1999_Proc.Natl.Acad.Sci.U.S.A_96_1100 |
| ESTHER : Song_1999_Proc.Natl.Acad.Sci.U.S.A_96_1100 |
| PubMedSearch : Song_1999_Proc.Natl.Acad.Sci.U.S.A_96_1100 |
| PubMedID: 9927700 |
| Gene_locus related to this paper: ratno-1neur |
| Title : Synaptic cell adhesion proteins and synaptogenesis in the mammalian central nervous system - Brose_1999_Naturwiss_86_516 |
| Author(s) : Brose N |
| Ref : Naturwissenschaften , 86 :516 , 1999 |
| Abstract : Brose_1999_Naturwiss_86_516 |
| ESTHER : Brose_1999_Naturwiss_86_516 |
| PubMedSearch : Brose_1999_Naturwiss_86_516 |
| PubMedID: 10551945 |
| Title : The making of neurexins - Missler_1998_J.Neurochem_71_1339 |
| Author(s) : Missler M , Fernandez-Chacon R , Sudhof TC |
| Ref : Journal of Neurochemistry , 71 :1339 , 1998 |
| Abstract : Missler_1998_J.Neurochem_71_1339 |
| ESTHER : Missler_1998_J.Neurochem_71_1339 |
| PubMedSearch : Missler_1998_J.Neurochem_71_1339 |
| PubMedID: 9751164 |
| Title : CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins - Kurschner_1998_Mol.Cell.Neurosci_11_161 |
| Author(s) : Kurschner C , Mermelstein PG , Holden WT , Surmeier DJ |
| Ref : Molecular & Cellular Neurosciences , 11 :161 , 1998 |
| Abstract : Kurschner_1998_Mol.Cell.Neurosci_11_161 |
| ESTHER : Kurschner_1998_Mol.Cell.Neurosci_11_161 |
| PubMedSearch : Kurschner_1998_Mol.Cell.Neurosci_11_161 |
| PubMedID: 9647694 |
| Title : Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis - Grifman_1998_Proc.Natl.Acad.Sci.U.S.A_95_13935 |
| Author(s) : Grifman M , Galyam N , Seidman S , Soreq H |
| Ref : Proc Natl Acad Sci U S A , 95 :13935 , 1998 |
| Abstract : Grifman_1998_Proc.Natl.Acad.Sci.U.S.A_95_13935 |
| ESTHER : Grifman_1998_Proc.Natl.Acad.Sci.U.S.A_95_13935 |
| PubMedSearch : Grifman_1998_Proc.Natl.Acad.Sci.U.S.A_95_13935 |
| PubMedID: 9811904 |
| Title : Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules - Nguyen_1997_J.Biol.Chem_272_26032 |
| Author(s) : Nguyen T , Sudhof TC |
| Ref : Journal of Biological Chemistry , 272 :26032 , 1997 |
| Abstract : Nguyen_1997_J.Biol.Chem_272_26032 |
| ESTHER : Nguyen_1997_J.Biol.Chem_272_26032 |
| PubMedSearch : Nguyen_1997_J.Biol.Chem_272_26032 |
| PubMedID: 9325340 |
| Gene_locus related to this paper: ratno-1neur |
| Title : Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration - Andres_1997_Proc.Natl.Acad.Sci.U.S.A_94_8173 |
| Author(s) : Andres C , Beeri R , Friedman A , Lev-Lehman E , Henis S , Timberg R , Shani M , Soreq H |
| Ref : Proc Natl Acad Sci U S A , 94 :8173 , 1997 |
| Abstract : Andres_1997_Proc.Natl.Acad.Sci.U.S.A_94_8173 |
| ESTHER : Andres_1997_Proc.Natl.Acad.Sci.U.S.A_94_8173 |
| PubMedSearch : Andres_1997_Proc.Natl.Acad.Sci.U.S.A_94_8173 |
| PubMedID: 9223334 |
| Title : Binding of neuroligins to PSD-95 - Irie_1997_Science_277_1511 |
| Author(s) : Irie M , Hata Y , Takeuchi M , Ichtchenko K , Toyoda A , Hirao K , Takai Y , Rosahl TW , Sudhof TC |
| Ref : Science , 277 :1511 , 1997 |
| Abstract : Irie_1997_Science_277_1511 |
| ESTHER : Irie_1997_Science_277_1511 |
| PubMedSearch : Irie_1997_Science_277_1511 |
| PubMedID: 9278515 |
| Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X |
| Title : Structures, alternative splicing, and neurexin binding of multiple neuroligins - Ichtchenko_1996_J.Biol.Chem_271_2676 |
| Author(s) : Ichtchenko K , Nguyen T , Sudhof TC |
| Ref : Journal of Biological Chemistry , 271 :2676 , 1996 |
| Abstract : Ichtchenko_1996_J.Biol.Chem_271_2676 |
| ESTHER : Ichtchenko_1996_J.Biol.Chem_271_2676 |
| PubMedSearch : Ichtchenko_1996_J.Biol.Chem_271_2676 |
| PubMedID: 8576240 |
| Gene_locus related to this paper: ratno-1neur , ratno-2neur , ratno-3neur |
| Title : Neuroligin 1: a splice site-specific ligand for beta-neurexins - Ichtchenko_1995_Cell_81_435 |
| Author(s) : Ichtchenko K , Hata Y , Nguyen T , Ullrich B , Missler M , Moomaw C , Sudhof TC |
| Ref : Cell , 81 :435 , 1995 |
| Abstract : Ichtchenko_1995_Cell_81_435 |
| ESTHER : Ichtchenko_1995_Cell_81_435 |
| PubMedSearch : Ichtchenko_1995_Cell_81_435 |
| PubMedID: 7736595 |
| Gene_locus related to this paper: ratno-1neur , ratno-2neur |
Structures (21)
Genes Proteins in Neuroligin family (517)
Fragments of genes in Neuroligin family (732)
Structures in Neuroligin family (21)No substrate
No Inhibitor