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| Title : Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease - Macedo_2022_Bioorg.Med.Chem_71_116952 |
| Author(s) : Macedo Vaz S , de Freitas Silva M , Dos Reis Rosa Franco G , Jorge RGM , Motta RdSF , Goncalves Castro N , Alvim Guedes I , Dardenne LE , Amaral Alves M , Garrett da Costa R , Beserra Pinheiro G , Germino Veras L , Renata Mortari M , Pruccoli L , Tarozzi A , Viegas C, Jr. |
| Ref : Bioorganic & Medicinal Chemistry , 71 :116952 , 2022 |
| Abstract : Macedo_2022_Bioorg.Med.Chem_71_116952 |
| ESTHER : Macedo_2022_Bioorg.Med.Chem_71_116952 |
| PubMedSearch : Macedo_2022_Bioorg.Med.Chem_71_116952 |
| PubMedID: 35930852 |
| Title : Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation - Cristancho_2022_RSC.Med.Chem_13_568 |
| Author(s) : Cristancho Ortiz CJ , de Freitas Silva M , Pruccoli L , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Leomil Coelho LF , Guimaraes MJ , da Silva FMR , Castro N , Gontijo VS , Rojas VCT , de Oliveira MK , Vilela FC , Giusti-Paiva A , Barbosa G , Lima LM , Pinheiro GB , Veras LG , Mortari MR , Tarozzi A , Viegas C, Jr. |
| Ref : RSC Med Chem , 13 :568 , 2022 |
| Abstract : Cristancho_2022_RSC.Med.Chem_13_568 |
| ESTHER : Cristancho_2022_RSC.Med.Chem_13_568 |
| PubMedSearch : Cristancho_2022_RSC.Med.Chem_13_568 |
| PubMedID: 35694691 |
| Title : Protective Effects of Chrysin against the Neurotoxicity Induced by Aluminium: In Vitro and In Vivo Studies - Campos_2021_Toxicology__153033 |
| Author(s) : Campos HM , da Costa M , da Silva Moreira LK , da Silva Neri HF , Branco da Silva CR , Pruccoli L , Dos Santos FCA , Costa EA , Tarozzi A , Ghedini PC |
| Ref : Toxicology , :153033 , 2021 |
| Abstract : Campos_2021_Toxicology__153033 |
| ESTHER : Campos_2021_Toxicology__153033 |
| PubMedSearch : Campos_2021_Toxicology__153033 |
| PubMedID: 34774662 |
| Title : Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease - de Freitas Silva_2020_Molecules_25_ |
| Author(s) : de Freitas Silva M , Tardelli Lima E , Pruccoli L , Castro NG , Guimares MJR , F MRdS , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Gontijo VS , Tarozzi A , Viegas C |
| Ref : Molecules , 25 : , 2020 |
| Abstract : de Freitas Silva_2020_Molecules_25_ |
| ESTHER : de Freitas Silva_2020_Molecules_25_ |
| PubMedSearch : de Freitas Silva_2020_Molecules_25_ |
| PubMedID: 32664425 |
| Title : PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease - Morroni_2019_Front.Pharmacol_10_658 |
| Author(s) : Morroni F , Sita G , Graziosi A , Ravegnini G , Molteni R , Paladini MS , Dias KST , Dos Santos AF , Viegas C, Jr. , Camps I , Pruccoli L , Tarozzi A , Hrelia P |
| Ref : Front Pharmacol , 10 :658 , 2019 |
| Abstract : Morroni_2019_Front.Pharmacol_10_658 |
| ESTHER : Morroni_2019_Front.Pharmacol_10_658 |
| PubMedSearch : Morroni_2019_Front.Pharmacol_10_658 |
| PubMedID: 31244664 |
| Title : Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment - Montanari_2019_Eur.J.Med.Chem_178_243 |
| Author(s) : Montanari S , Mahmoud AM , Pruccoli L , Rabbito A , Naldi M , Petralla S , Moraleda I , Bartolini M , Monti B , Iriepa I , Belluti F , Gobbi S , Di Marzo V , Bisi A , Tarozzi A , Ligresti A , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 178 :243 , 2019 |
| Abstract : Montanari_2019_Eur.J.Med.Chem_178_243 |
| ESTHER : Montanari_2019_Eur.J.Med.Chem_178_243 |
| PubMedSearch : Montanari_2019_Eur.J.Med.Chem_178_243 |
| PubMedID: 31185414 |
| Title : Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease - Rampa_2018_Molecules_23_ |
| Author(s) : Rampa A , Bartolini M , Pruccoli L , Naldi M , Iriepa I , Moraleda I , Belluti F , Gobbi S , Tarozzi A , Bisi A |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Rampa_2018_Molecules_23_ |
| ESTHER : Rampa_2018_Molecules_23_ |
| PubMedSearch : Rampa_2018_Molecules_23_ |
| PubMedID: 30061534 |
| Title : Chalcone-based carbamates for Alzheimer's disease treatment - Rampa_2017_Future.Med.Chem_9_749 |
| Author(s) : Rampa A , Montanari S , Pruccoli L , Bartolini M , Falchi F , Feoli A , Cavalli A , Belluti F , Gobbi S , Tarozzi A , Bisi A |
| Ref : Future Med Chem , 9 :749 , 2017 |
| Abstract : Rampa_2017_Future.Med.Chem_9_749 |
| ESTHER : Rampa_2017_Future.Med.Chem_9_749 |
| PubMedSearch : Rampa_2017_Future.Med.Chem_9_749 |
| PubMedID: 28498775 |
| Title : Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease - Dias_2017_Eur.J.Med.Chem_130_440 |
| Author(s) : Dias KS , de Paula CT , Dos Santos T , Souza IN , Boni MS , Guimaraes MJ , da Silva FM , Castro NG , Neves GA , Veloso CC , Coelho MM , de Melo IS , Giusti FC , Giusti-Paiva A , da Silva ML , Dardenne LE , Guedes IA , Pruccoli L , Morroni F , Tarozzi A , Viegas C, Jr. |
| Ref : Eur Journal of Medicinal Chemistry , 130 :440 , 2017 |
| Abstract : Dias_2017_Eur.J.Med.Chem_130_440 |
| ESTHER : Dias_2017_Eur.J.Med.Chem_130_440 |
| PubMedSearch : Dias_2017_Eur.J.Med.Chem_130_440 |
| PubMedID: 28282613 |
| Title : Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives - Montanari_2016_ChemMedChem_11_1296 |
| Author(s) : Montanari S , Bartolini M , Neviani P , Belluti F , Gobbi S , Pruccoli L , Tarozzi A , Falchi F , Andrisano V , Miszta P , Cavalli A , Filipek S , Bisi A , Rampa A |
| Ref : ChemMedChem , 11 :1296 , 2016 |
| Abstract : Montanari_2016_ChemMedChem_11_1296 |
| ESTHER : Montanari_2016_ChemMedChem_11_1296 |
| PubMedSearch : Montanari_2016_ChemMedChem_11_1296 |
| PubMedID: 26507467 |
| Title : Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease - Belluti_2014_Eur.J.Med.Chem_78C_157 |
| Author(s) : Belluti F , De Simone A , Tarozzi A , Bartolini M , Djemil A , Bisi A , Gobbi S , Montanari S , Cavalli A , Andrisano V , Bottegoni G , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 78C :157 , 2014 |
| Abstract : Belluti_2014_Eur.J.Med.Chem_78C_157 |
| ESTHER : Belluti_2014_Eur.J.Med.Chem_78C_157 |
| PubMedSearch : Belluti_2014_Eur.J.Med.Chem_78C_157 |
| PubMedID: 24681980 |
| Title : From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease - Tarozzi_2014_Pharmacol.Res.Perspect_2_e00023 |
| Author(s) : Tarozzi A , Bartolini M , Piazzi L , Valgimigli L , Amorati R , Bolondi C , Djemil A , Mancini F , Andrisano V , Rampa A |
| Ref : Pharmacol Res Perspect , 2 :e00023 , 2014 |
| Abstract : Tarozzi_2014_Pharmacol.Res.Perspect_2_e00023 |
| ESTHER : Tarozzi_2014_Pharmacol.Res.Perspect_2_e00023 |
| PubMedSearch : Tarozzi_2014_Pharmacol.Res.Perspect_2_e00023 |
| PubMedID: 25505579 |
| Title : Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease - Rosini_2011_Eur.J.Med.Chem_46_5435 |
| Author(s) : Rosini M , Simoni E , Bartolini M , Tarozzi A , Matera R , Milelli A , Hrelia P , Andrisano V , Bolognesi ML , Melchiorre C |
| Ref : Eur Journal of Medicinal Chemistry , 46 :5435 , 2011 |
| Abstract : Rosini_2011_Eur.J.Med.Chem_46_5435 |
| ESTHER : Rosini_2011_Eur.J.Med.Chem_46_5435 |
| PubMedSearch : Rosini_2011_Eur.J.Med.Chem_46_5435 |
| PubMedID: 21924801 |
| Title : Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush - Rosini_2008_J.Med.Chem_51_4381 |
| Author(s) : Rosini M , Simoni E , Bartolini M , Cavalli A , Ceccarini L , Pascu N , McClymont DW , Tarozzi A , Bolognesi ML , Minarini A , Tumiatti V , Andrisano V , Mellor IR , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 51 :4381 , 2008 |
| Abstract : Rosini_2008_J.Med.Chem_51_4381 |
| ESTHER : Rosini_2008_J.Med.Chem_51_4381 |
| PubMedSearch : Rosini_2008_J.Med.Chem_51_4381 |
| PubMedID: 18605718 |
| Title : Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity - Rizzo_2008_J.Med.Chem_51_2883 |
| Author(s) : Rizzo S , Riviere C , Piazzi L , Bisi A , Gobbi S , Bartolini M , Andrisano V , Morroni F , Tarozzi A , Monti JP , Rampa A |
| Ref : Journal of Medicinal Chemistry , 51 :2883 , 2008 |
| Abstract : Rizzo_2008_J.Med.Chem_51_2883 |
| ESTHER : Rizzo_2008_J.Med.Chem_51_2883 |
| PubMedSearch : Rizzo_2008_J.Med.Chem_51_2883 |
| PubMedID: 18419109 |
| Title : Rational approach to discover multipotent anti-Alzheimer drugs - Rosini_2005_J.Med.Chem_48_360 |
| Author(s) : Rosini M , Andrisano V , Bartolini M , Bolognesi ML , Hrelia P , Minarini A , Tarozzi A , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 48 :360 , 2005 |
| Abstract : Rosini_2005_J.Med.Chem_48_360 |
| ESTHER : Rosini_2005_J.Med.Chem_48_360 |
| PubMedSearch : Rosini_2005_J.Med.Chem_48_360 |
| PubMedID: 15658850 |