Full name : Ordentlich Arie
First name : Arie
Mail : Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona 70450, Israel
Zip Code :
City :
Country : Israel
Email : ordentl@.sharmin
Phone : 972-8-381442
Fax : 972-8-401404
Website :
Directory :
| Title : Next generation OP-bioscavengers: a circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics - Kronman_2010_Chem.Biol.Interact_187_253 |
| Author(s) : Kronman C , Cohen O , Mazor O , Ordentlich A , Raveh L , Velan B , Shafferman A |
| Ref : Chemico-Biological Interactions , 187 :253 , 2010 |
| Abstract : Kronman_2010_Chem.Biol.Interact_187_253 |
| ESTHER : Kronman_2010_Chem.Biol.Interact_187_253 |
| PubMedSearch : Kronman_2010_Chem.Biol.Interact_187_253 |
| PubMedID: 20005217 |
| Title : Isolation and chimerization of a highly neutralizing antibody conferring passive protection against lethal Bacillus anthracis infection - Rosenfeld_2009_PLoS.One_4_e6351 |
| Author(s) : Rosenfeld R , Marcus H , Ben-Arie E , Lachmi BE , Mechaly A , Reuveny S , Gat O , Mazor O , Ordentlich A |
| Ref : PLoS ONE , 4 :e6351 , 2009 |
| Abstract : Rosenfeld_2009_PLoS.One_4_e6351 |
| ESTHER : Rosenfeld_2009_PLoS.One_4_e6351 |
| PubMedSearch : Rosenfeld_2009_PLoS.One_4_e6351 |
| PubMedID: 19629185 |
| Title : Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions - Barak_2009_Biochem.J_417_213 |
| Author(s) : Barak D , Ordentlich A , Stein D , Yu QS , Greig NH , Shafferman A |
| Ref : Biochemical Journal , 417 :213 , 2009 |
| Abstract : Barak_2009_Biochem.J_417_213 |
| ESTHER : Barak_2009_Biochem.J_417_213 |
| PubMedSearch : Barak_2009_Biochem.J_417_213 |
| PubMedID: 18729824 |
| Title : Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response - Lustig_2009_Vaccine_27_1691 |
| Author(s) : Lustig S , Maik-Rachline G , Paran N , Melamed S , Israely T , Erez N , Orr N , Reuveny S , Ordentlich A , Laub O , Shafferman A , Velan B |
| Ref : Vaccine , 27 :1691 , 2009 |
| Abstract : Lustig_2009_Vaccine_27_1691 |
| ESTHER : Lustig_2009_Vaccine_27_1691 |
| PubMedSearch : Lustig_2009_Vaccine_27_1691 |
| PubMedID: 19195492 |
| Title : Flexibility versus rigidity of the functional architecture of AChE active center - Shafferman_2008_Chem.Biol.Interact_175_166 |
| Author(s) : Shafferman A , Barak D , Stein D , Kronman C , Velan B , Greig NH , Ordentlich A |
| Ref : Chemico-Biological Interactions , 175 :166 , 2008 |
| Abstract : Shafferman_2008_Chem.Biol.Interact_175_166 |
| ESTHER : Shafferman_2008_Chem.Biol.Interact_175_166 |
| PubMedSearch : Shafferman_2008_Chem.Biol.Interact_175_166 |
| PubMedID: 18471807 |
| Title : Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase - Mazor_2008_Mol.Pharmacol_74_755 |
| Author(s) : Mazor O , Cohen O , Kronman C , Raveh L , Stein D , Ordentlich A , Shafferman A |
| Ref : Molecular Pharmacology , 74 :755 , 2008 |
| Abstract : Mazor_2008_Mol.Pharmacol_74_755 |
| ESTHER : Mazor_2008_Mol.Pharmacol_74_755 |
| PubMedSearch : Mazor_2008_Mol.Pharmacol_74_755 |
| PubMedID: 18523134 |
| Title : Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication - Kronman_2007_Toxicology_233_40 |
| Author(s) : Kronman C , Cohen O , Raveh L , Mazor O , Ordentlich A , Shafferman A |
| Ref : Toxicology , 233 :40 , 2007 |
| Abstract : Kronman_2007_Toxicology_233_40 |
| ESTHER : Kronman_2007_Toxicology_233_40 |
| PubMedSearch : Kronman_2007_Toxicology_233_40 |
| PubMedID: 17045722 |
| Title : Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds - Cohen_2006_Mol.Pharmacol_70_1121 |
| Author(s) : Cohen O , Kronman C , Raveh L , Mazor O , Ordentlich A , Shafferman A |
| Ref : Molecular Pharmacology , 70 :1121 , 2006 |
| Abstract : Cohen_2006_Mol.Pharmacol_70_1121 |
| ESTHER : Cohen_2006_Mol.Pharmacol_70_1121 |
| PubMedSearch : Cohen_2006_Mol.Pharmacol_70_1121 |
| PubMedID: 16801396 |
| Title : Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents - Barak_2005_Chem.Biol.Interact_157-158_219 |
| Author(s) : Barak D , Ordentlich A , Kaplan D , Kronman C , Velan B , Shafferman A |
| Ref : Chemico-Biological Interactions , 157-158 :219 , 2005 |
| Abstract : Barak_2005_Chem.Biol.Interact_157-158_219 |
| ESTHER : Barak_2005_Chem.Biol.Interact_157-158_219 |
| PubMedSearch : Barak_2005_Chem.Biol.Interact_157-158_219 |
| PubMedID: 16289124 |
| Title : The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers - Ordentlich_2005_Chem.Biol.Interact_157-158_191 |
| Author(s) : Ordentlich A , Barak D , Sod-Moriah G , Kaplan D , Mizrahi D , Segall Y , Kronman C , Karton Y , Lazar A , Marcus D , Velan B , Shafferman A |
| Ref : Chemico-Biological Interactions , 157-158 :191 , 2005 |
| Abstract : Ordentlich_2005_Chem.Biol.Interact_157-158_191 |
| ESTHER : Ordentlich_2005_Chem.Biol.Interact_157-158_191 |
| PubMedSearch : Ordentlich_2005_Chem.Biol.Interact_157-158_191 |
| PubMedID: 16289014 |
| Title : Functional requirements for the optimal catalytic configuration of the AChE active center - Shafferman_2005_Chem.Biol.Interact_157-158_123 |
| Author(s) : Shafferman A , Barak D , Kaplan D , Ordentlich A , Kronman C , Velan B |
| Ref : Chemico-Biological Interactions , 157-158 :123 , 2005 |
| Abstract : Shafferman_2005_Chem.Biol.Interact_157-158_123 |
| ESTHER : Shafferman_2005_Chem.Biol.Interact_157-158_123 |
| PubMedSearch : Shafferman_2005_Chem.Biol.Interact_157-158_123 |
| PubMedID: 16256968 |
| Title : MALDI-TOF\/MS analysis of tabun-acetylcholinesterase conjugate. - |
| Author(s) : Elhanany E , Ordentlich A , Dgany OR , Kaplan D , Segall Y , Barak R , Velan B , Shafferman A |
| Ref : Cholinergic Mechanisms, CRC Press :563 , 2004 |
| PubMedID: |
| Title : Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE - Ordentlich_2004_Biochemistry_43_11255 |
| Author(s) : Ordentlich A , Barak D , Sod-Moriah G , Kaplan D , Mizrahi D , Segall Y , Kronman C , Karton Y , Lazar A , Marcus D , Velan B , Shafferman A |
| Ref : Biochemistry , 43 :11255 , 2004 |
| Abstract : Ordentlich_2004_Biochemistry_43_11255 |
| ESTHER : Ordentlich_2004_Biochemistry_43_11255 |
| PubMedSearch : Ordentlich_2004_Biochemistry_43_11255 |
| PubMedID: 15366935 |
| Title : Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase? - Kaplan_2004_Biochemistry_43_3129 |
| Author(s) : Kaplan D , Barak D , Ordentlich A , Kronman C , Velan B , Shafferman A |
| Ref : Biochemistry , 43 :3129 , 2004 |
| Abstract : Kaplan_2004_Biochemistry_43_3129 |
| ESTHER : Kaplan_2004_Biochemistry_43_3129 |
| PubMedSearch : Kaplan_2004_Biochemistry_43_3129 |
| PubMedID: 15023064 |
| Title : Poster (14) The aromatic trapping of histidine 447 in catalysis of acetylcholinesterases - |
| Author(s) : Shafferman A , Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :327 , 2004 |
| PubMedID: |
| Title : The aromatic trapping of histidine 447 in catalysis of acetylcholinesterases - |
| Author(s) : Shafferman A , Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :181 , 2004 |
| PubMedID: |
| Title : Surprising findings from the functional analysis of human acetylcholinesterase adducts of Alzheimer?s disease drugs. - |
| Author(s) : Ordentlich A , Barak D , Ariel N , Kronman C , Kaplan D , Velan B , Shafferman A |
| Ref : Cholinergic Mechanisms, CRC Press :177 , 2004 |
| PubMedID: |
| Title : Poster (21) Analysis of acetylcholinesterase adducts of alzheimer's drugs - |
| Author(s) : Ordentlich A , Kronman C , Barak D , Ariel N , Kaplan D , Velan B , Shafferman A |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :332 , 2004 |
| PubMedID: |
| Title : Poster (23) Phosphorylation and aging of AChE - insights from mutagenesis, mass spectrometry and structural studies - |
| Author(s) : Barak D , Ordentlich A , Kaplan D , Elhanani E , Segall Y , Barak R , Velan B , Shafferman A |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :332 , 2004 |
| PubMedID: |
| Title : Poster (35) The hierarchy of post-translation modifications determining circulatory longevity of acetylcholinesterase. - |
| Author(s) : Velan B , Kronman C , Chitlaru T , Cohen O , Ordentlich A , Shafferman A |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :339 , 2004 |
| PubMedID: |
| Title : Generation of pharmacokinetically improved recombinant human acetylcholinesterase by polyethylene glycol modification. - |
| Author(s) : Cohen O , Kronman C , Chitlaru T , Ordentlich A , Velan B , Shafferman A |
| Ref : Cholinergic Mechanisms, CRC Press :519 , 2004 |
| PubMedID: |
| Title : Attempts to engineer an enzyme mimic of butyrylcholinesterase by substitution of the six divergent aromatic amino acids in the active center of acetylcholinesterase. - |
| Author(s) : Kaplan D , Ordentlich A , Barak D , Ariel N , Kronman C , Baruch V , Shafferman A |
| Ref : Cholinergic Mechanisms, CRC Press :601 , 2004 |
| PubMedID: |
| Title : A complex array of post-translation modifications determines the circulatory longevity of acetylcholinesterase in a hierarchical manner. - |
| Author(s) : Shafferman A , Chitlaru T , Ordentlich A , Velan B , Kronman C |
| Ref : Cholinergic Mechanisms, CRC Press :245 , 2004 |
| PubMedID: |
| Title : Pressure and heat inactivation of recombinant human acetylcholinesterase. Importance of residue E202 for enzyme stability - Clery-Barraud_2002_Eur.J.Biochem_269_4297 |
| Author(s) : Clery-Barraud C , Ordentlich A , Grosfeld H , Shafferman A , Masson P |
| Ref : European Journal of Biochemistry , 269 :4297 , 2002 |
| Abstract : Clery-Barraud_2002_Eur.J.Biochem_269_4297 |
| ESTHER : Clery-Barraud_2002_Eur.J.Biochem_269_4297 |
| PubMedSearch : Clery-Barraud_2002_Eur.J.Biochem_269_4297 |
| PubMedID: 12199708 |
| Title : The aromatic trapping of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase - Barak_2002_Biochemistry_41_8245 |
| Author(s) : Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B , Shafferman A |
| Ref : Biochemistry , 41 :8245 , 2002 |
| Abstract : Barak_2002_Biochemistry_41_8245 |
| ESTHER : Barak_2002_Biochemistry_41_8245 |
| PubMedSearch : Barak_2002_Biochemistry_41_8245 |
| PubMedID: 12081473 |
| Title : Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: maldi-tof\/ms analysis of various nerve agent phosphyl adducts - Elhanany_2001_Chem.Res.Toxicol_14_912 |
| Author(s) : Elhanany E , Ordentlich A , Dgany O , Kaplan D , Segall Y , Barak R , Velan B , Shafferman A |
| Ref : Chemical Research in Toxicology , 14 :912 , 2001 |
| Abstract : Elhanany_2001_Chem.Res.Toxicol_14_912 |
| ESTHER : Elhanany_2001_Chem.Res.Toxicol_14_912 |
| PubMedSearch : Elhanany_2001_Chem.Res.Toxicol_14_912 |
| PubMedID: 11453739 |
| Title : Does butyrylization of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? - Kaplan_2001_Biochemistry_40_7433 |
| Author(s) : Kaplan D , Ordentlich A , Barak D , Ariel N , Kronman C , Velan B , Shafferman A |
| Ref : Biochemistry , 40 :7433 , 2001 |
| Abstract : Kaplan_2001_Biochemistry_40_7433 |
| ESTHER : Kaplan_2001_Biochemistry_40_7433 |
| PubMedSearch : Kaplan_2001_Biochemistry_40_7433 |
| PubMedID: 11412096 |
| Title : Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity - Cohen_2001_Biochem.J_357_795 |
| Author(s) : Cohen O , Kronman C , Chitlaru T , Ordentlich A , Velan B , Shafferman A |
| Ref : Biochemical Journal , 357 :795 , 2001 |
| Abstract : Cohen_2001_Biochem.J_357_795 |
| ESTHER : Cohen_2001_Biochem.J_357_795 |
| PubMedSearch : Cohen_2001_Biochem.J_357_795 |
| PubMedID: 11463350 |
| Title : Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase - Barak_2000_Biochemistry_39_1156 |
| Author(s) : Barak D , Ordentlich A , Kaplan D , Barak R , Mizrahi D , Kronman C , Segall Y , Velan B , Shafferman A |
| Ref : Biochemistry , 39 :1156 , 2000 |
| Abstract : Barak_2000_Biochemistry_39_1156 |
| ESTHER : Barak_2000_Biochemistry_39_1156 |
| PubMedSearch : Barak_2000_Biochemistry_39_1156 |
| PubMedID: 10653663 |
| Title : Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level - Millard_1999_Biochemistry_38_7032 |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Greenblatt HM , Harel M , Raves ML , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : Biochemistry , 38 :7032 , 1999 |
| Abstract : Millard_1999_Biochemistry_38_7032 |
| ESTHER : Millard_1999_Biochemistry_38_7032 |
| PubMedSearch : Millard_1999_Biochemistry_38_7032 |
| PubMedID: 10353814 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Reaction Products of Acetylcholinesterase and Vx Reveal a Mobile Histidine in the Catalytic Triad - Millard_1999_J.Am.Chem.Soc_121_9883 |
| Author(s) : Millard CB , Koellner G , Ordentlich A , Shafferman A , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 121 :9883 , 1999 |
| Abstract : Millard_1999_J.Am.Chem.Soc_121_9883 |
| ESTHER : Millard_1999_J.Am.Chem.Soc_121_9883 |
| PubMedSearch : Millard_1999_J.Am.Chem.Soc_121_9883 |
| PubMedID: |
| Gene_locus related to this paper: torca-ACHE |
| Title : A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase - Silman_1999_Chem.Biol.Interact_119-120_43 |
| Author(s) : Silman I , Millard CB , Ordentlich A , Greenblatt HM , Harel M , Barak D , Shafferman A , Sussman JL |
| Ref : Chemico-Biological Interactions , 119-120 :43 , 1999 |
| Abstract : Silman_1999_Chem.Biol.Interact_119-120_43 |
| ESTHER : Silman_1999_Chem.Biol.Interact_119-120_43 |
| PubMedSearch : Silman_1999_Chem.Biol.Interact_119-120_43 |
| PubMedID: 10421437 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers - Ordentlich_1999_Biochemistry_38_3055 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Benschop HP , De Jong LP , Ariel N , Barak R , Segall Y , Velan B , Shafferman A |
| Ref : Biochemistry , 38 :3055 , 1999 |
| Abstract : Ordentlich_1999_Biochemistry_38_3055 |
| ESTHER : Ordentlich_1999_Biochemistry_38_3055 |
| PubMedSearch : Ordentlich_1999_Biochemistry_38_3055 |
| PubMedID: 10074358 |
| Title : Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase - |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998 |
| PubMedID: |
| Title : Bovine Acetylcholinestrase Cloning, Expression and Characterization of the Recombinant Enzyme - |
| Author(s) : Mendelson I , Kronman C , Zeliger N , Seri T , Ordentlich A , Shafferman A , Velan B |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :148 , 1998 |
| PubMedID: |
| Title : Structural Modifications of the Omega Loop in Human Acetylcholinesterase - |
| Author(s) : Ariel N , Velan B , Barak D , Leitner M , Bino T , Ordentlich A , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :453 , 1998 |
| PubMedID: |
| Title : Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase - |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :454 , 1998 |
| PubMedID: |
| Title : The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors - Ariel_1998_Biochem.J_335_95 |
| Author(s) : Ariel N , Ordentlich A , Barak D , Bino T , Velan B , Shafferman A |
| Ref : Biochemical Journal , 335 :95 , 1998 |
| Abstract : Ariel_1998_Biochem.J_335_95 |
| ESTHER : Ariel_1998_Biochem.J_335_95 |
| PubMedSearch : Ariel_1998_Biochem.J_335_95 |
| PubMedID: 9742217 |
| Title : Contribution of the Active Center Functional Architecture to AChE Reactivity Toward Substrates and Inhibitors - |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ariel N , Velan B |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :203 , 1998 |
| PubMedID: |
| Title : Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels - Chitlaru_1998_Biochem.J_336_647 |
| Author(s) : Chitlaru T , Kronman C , Zeevi M , Kam M , Harel A , Ordentlich A , Velan B , Shafferman A |
| Ref : Biochemical Journal , 336 :647 , 1998 |
| Abstract : Chitlaru_1998_Biochem.J_336_647 |
| ESTHER : Chitlaru_1998_Biochem.J_336_647 |
| PubMedSearch : Chitlaru_1998_Biochem.J_336_647 |
| PubMedID: 9841877 |
| Title : Does Electrostatic Attraction or Steering by Charged Residues within the Gorge Contribute to the Reactivity of AChE? - |
| Author(s) : Ordentlich A , Barak D , Stein D , Berman D , Kronman C , Ariel N , Velan B , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :234 , 1998 |
| PubMedID: |
| Title : The Aromatic Moiety at Position-86 of HuAChE Accelerate the Aging of Phosphonyl-AChE Conjugates through Cation- Interactions - |
| Author(s) : Barak D , Ordentlich A , Stein D , Segall Y , Velan B , Benschop HP , De Jong LP , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :246 , 1998 |
| PubMedID: |
| Title : ESMS as a Unique Tool for the Molecular Monitoring of Reactions between HuAChE and Various OP-Agents - |
| Author(s) : Ordentlich A , Barak R , Barak D , Fischer M , Benschop HP , De Jong LP , Segall Y , Velan B , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :249 , 1998 |
| PubMedID: |
| Title : Contribution of Primary Sequence and Post-Translation Modification to the Pharmacokinetics of Human and Bovine Acetylcholinesterases - |
| Author(s) : Velan B , Kronman C , Chitlaru T , Mendelson I , Ordentlich A , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :291 , 1998 |
| PubMedID: |
| Title : Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase - |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998 |
| PubMedID: |
| Gene_locus related to this paper: torca-ACHE |
| Title : Functional characteristics of the oxyanion hole in human acetylcholinesterase - Ordentlich_1998_J.Biol.Chem_273_19509 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 273 :19509 , 1998 |
| Abstract : Ordentlich_1998_J.Biol.Chem_273_19509 |
| ESTHER : Ordentlich_1998_J.Biol.Chem_273_19509 |
| PubMedSearch : Ordentlich_1998_J.Biol.Chem_273_19509 |
| PubMedID: 9677373 |
| Title : Compatibility of Structures Inferred from Mutagenesis and from X-Ray Crystallography for Various AChE Complexes - |
| Author(s) : Ariel N , Ordentlich A , Barak D , Bino T , Velan B , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :375 , 1998 |
| PubMedID: |
| Title : Aging of somanyl-acetylcholinesterase adducts: facts and models [letter] - |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Stein D , Ariel N , Velan B |
| Ref : Biochemical Journal , 324 :996 , 1997 |
| PubMedID: 9235881 |
| Title : Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray- ionization mass spectrometry - Barak_1997_FEBS.Lett_407_347 |
| Author(s) : Barak R , Ordentlich A , Barak D , Fischer M , Benschop HP , De Jong LP , Segall Y , Velan B , Shafferman A |
| Ref : FEBS Letters , 407 :347 , 1997 |
| Abstract : Barak_1997_FEBS.Lett_407_347 |
| ESTHER : Barak_1997_FEBS.Lett_407_347 |
| PubMedSearch : Barak_1997_FEBS.Lett_407_347 |
| PubMedID: 9175882 |
| Title : Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives - Grosfeld_1996_Mol.Pharmacol_50_639 |
| Author(s) : Grosfeld H , Barak D , Ordentlich A , Velan B , Shafferman A |
| Ref : Molecular Pharmacology , 50 :639 , 1996 |
| Abstract : Grosfeld_1996_Mol.Pharmacol_50_639 |
| ESTHER : Grosfeld_1996_Mol.Pharmacol_50_639 |
| PubMedSearch : Grosfeld_1996_Mol.Pharmacol_50_639 |
| PubMedID: 8794905 |
| Title : The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors - Ordentlich_1996_J.Biol.Chem_271_11953 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 271 :11953 , 1996 |
| Abstract : Ordentlich_1996_J.Biol.Chem_271_11953 |
| ESTHER : Ordentlich_1996_J.Biol.Chem_271_11953 |
| PubMedSearch : Ordentlich_1996_J.Biol.Chem_271_11953 |
| PubMedID: 8662593 |
| Title : Structural modifications of the omega loop in human acetylcholinesterase - Velan_1996_FEBS.Lett_395_22 |
| Author(s) : Velan B , Barak D , Ariel N , Leitner M , Bino T , Ordentlich A , Shafferman A |
| Ref : FEBS Letters , 395 :22 , 1996 |
| Abstract : Velan_1996_FEBS.Lett_395_22 |
| ESTHER : Velan_1996_FEBS.Lett_395_22 |
| PubMedSearch : Velan_1996_FEBS.Lett_395_22 |
| PubMedID: 8849682 |
| Title : Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre - Shafferman_1996_Biochem.J_318_833 |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Stein D , Ariel N , Velan B |
| Ref : Biochemical Journal , 318 :833 , 1996 |
| Abstract : Shafferman_1996_Biochem.J_318_833 |
| ESTHER : Shafferman_1996_Biochem.J_318_833 |
| PubMedSearch : Shafferman_1996_Biochem.J_318_833 |
| PubMedID: 8836126 |
| Title : Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase - Ordentlich_1995_J.Biol.Chem_270_2082 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 270 :2082 , 1995 |
| Abstract : Ordentlich_1995_J.Biol.Chem_270_2082 |
| ESTHER : Ordentlich_1995_J.Biol.Chem_270_2082 |
| PubMedSearch : Ordentlich_1995_J.Biol.Chem_270_2082 |
| PubMedID: 7836436 |
| Title : Electrostatic Attraction by Surface Charge does not Contribute to the Catalytic Efficiency of Acetylcholinesterase - |
| Author(s) : Barak D , Ordentlich A , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B , Shafferman A |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :223 , 1995 |
| PubMedID: |
| Title : Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite - Barak_1995_Biochemistry_34_15444 |
| Author(s) : Barak D , Ordentlich A , Bromberg A , Kronman C , Marcus D , Lazar A , Ariel N , Velan B , Shafferman A |
| Ref : Biochemistry , 34 :15444 , 1995 |
| Abstract : Barak_1995_Biochemistry_34_15444 |
| ESTHER : Barak_1995_Biochemistry_34_15444 |
| PubMedSearch : Barak_1995_Biochemistry_34_15444 |
| PubMedID: 7492545 |
| Title : Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases - |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ariel N , Leitner M , Segall Y , Bromberg A , Reuveny S , Marcus D , Bino T , Lazar A , Cohen S , Velan B |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :189 , 1995 |
| PubMedID: |
| Title : Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation - Kronman_1995_Biochem.J_311_959 |
| Author(s) : Kronman C , Velan B , Marcus D , Ordentlich A , Reuveny S , Shafferman A |
| Ref : Biochemical Journal , 311 :959 , 1995 |
| Abstract : Kronman_1995_Biochem.J_311_959 |
| ESTHER : Kronman_1995_Biochem.J_311_959 |
| PubMedSearch : Kronman_1995_Biochem.J_311_959 |
| PubMedID: 7487957 |
| Title : Compilation of Evaluated Mutants of Cholinesterases - |
| Author(s) : Shafferman A , Kronman C , Ordentlich A |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :481 , 1995 |
| PubMedID: |
| Title : Amino Acids Determining Specificity to OP-Agents and Facilitating the Aging Process in Human Acetylcholinesterase - |
| Author(s) : Ordentlich A , Kronman C , Stein D , Ariel N , Reuveny S , Marcus D , Segall Y , Barak D , Velan B , Shafferman A |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :221 , 1995 |
| PubMedID: |
| Title : Post-Translation Processing of Acetylcholinesterase - |
| Author(s) : Velan B , Kronman C , Ordentlich A , Flashner Y , Ber R |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :269 , 1995 |
| PubMedID: |
| Title : Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core - Barak_1994_J.Biol.Chem_269_6296 |
| Author(s) : Barak D , Kronman C , Ordentlich A , Ariel N , Bromberg A , Marcus D , Lazar A , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 269 :6296 , 1994 |
| Abstract : Barak_1994_J.Biol.Chem_269_6296 |
| ESTHER : Barak_1994_J.Biol.Chem_269_6296 |
| PubMedSearch : Barak_1994_J.Biol.Chem_269_6296 |
| PubMedID: 8119978 |
| Title : The back door hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis - Kronman_1994_J.Biol.Chem_269_27819 |
| Author(s) : Kronman C , Ordentlich A , Barak D , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 269 :27819 , 1994 |
| Abstract : Kronman_1994_J.Biol.Chem_269_27819 |
| ESTHER : Kronman_1994_J.Biol.Chem_269_27819 |
| PubMedSearch : Kronman_1994_J.Biol.Chem_269_27819 |
| PubMedID: 7961709 |
| Title : Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase - Shafferman_1994_EMBO.J_13_3448 |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B |
| Ref : EMBO Journal , 13 :3448 , 1994 |
| Abstract : Shafferman_1994_EMBO.J_13_3448 |
| ESTHER : Shafferman_1994_EMBO.J_13_3448 |
| PubMedSearch : Shafferman_1994_EMBO.J_13_3448 |
| PubMedID: 8062821 |
| Title : N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis - Velan_1993_Biochem.J_296_649 |
| Author(s) : Velan B , Kronman C , Ordentlich A , Flashner Y , Leitner M , Cohen S , Shafferman A |
| Ref : Biochemical Journal , 296 :649 , 1993 |
| Abstract : Velan_1993_Biochem.J_296_649 |
| ESTHER : Velan_1993_Biochem.J_296_649 |
| PubMedSearch : Velan_1993_Biochem.J_296_649 |
| PubMedID: 8280063 |
| Title : Recombinant human acetylcholinesterase - Enzyme engineering - |
| Author(s) : Shafferman A , Velan B , Barak D , Kronman C , Ordentlich A , Flashner Y , Leitner M , Segal Y , Grosfeld H , Stein D , Ariel N |
| Ref : Medical Defense Bioscience Review , 3 :1097 , 1993 |
| PubMedID: |
| Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 268 :17083 , 1993 |
| Abstract : Ordentlich_1993_J.Biol.Chem_268_17083 |
| ESTHER : Ordentlich_1993_J.Biol.Chem_268_17083 |
| PubMedSearch : Ordentlich_1993_J.Biol.Chem_268_17083 |
| PubMedID: 8349597 |
| Gene_locus related to this paper: human-ACHE , human-BCHE |
| Title : Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center - Ordentlich_1993_FEBS.Lett_334_215 |
| Author(s) : Ordentlich A , Kronman C , Barak D , Stein D , Ariel N , Marcus D , Velan B , Shafferman A |
| Ref : FEBS Letters , 334 :215 , 1993 |
| Abstract : Ordentlich_1993_FEBS.Lett_334_215 |
| ESTHER : Ordentlich_1993_FEBS.Lett_334_215 |
| PubMedSearch : Ordentlich_1993_FEBS.Lett_334_215 |
| PubMedID: 8224249 |
| Title : Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center - Shafferman_1992_EMBO.J_11_3561 |
| Author(s) : Shafferman A , Velan B , Ordentlich A , Kronman C , Grosfeld H , Leitner M , Flashner Y , Cohen S , Barak D , Ariel N |
| Ref : EMBO Journal , 11 :3561 , 1992 |
| Abstract : Shafferman_1992_EMBO.J_11_3561 |
| ESTHER : Shafferman_1992_EMBO.J_11_3561 |
| PubMedSearch : Shafferman_1992_EMBO.J_11_3561 |
| PubMedID: 1396557 |
| Title : Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding - Shafferman_1992_J.Biol.Chem_267_17640 |
| Author(s) : Shafferman A , Kronman C , Flashner Y , Leitner M , Grosfeld H , Ordentlich A , Gozes Y , Cohen S , Ariel N , Barak D , Harel M , Silman I , Sussman JL , Velan B |
| Ref : Journal of Biological Chemistry , 267 :17640 , 1992 |
| Abstract : Shafferman_1992_J.Biol.Chem_267_17640 |
| ESTHER : Shafferman_1992_J.Biol.Chem_267_17640 |
| PubMedSearch : Shafferman_1992_J.Biol.Chem_267_17640 |
| PubMedID: 1517212 |