ESTHER Database

The web site for the the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 ESTHER successfully switched to its new operating system on April 2 - long life to the new ESTHER server! There are still many pages from the old server that need to be implemented: we are working, and apologize for the delay Thermodynamics of the hyperthermostable carboxylesterase from Anoxybacillus geothermalis D9 9baci-EstD9 is further characterized by Johan et al. Quinone methide precursors developped as nonoxime reactivators of organophosphorus-inhibited cholinesterases and resurrectors of organophosphorus-aged acetylcholinesterase are described by Clay et al. and Lovins et al. Structure-based characterization and improvement of an enzymatic activity of Acremonium alcalophilum (Sodiomyces alcalophilus) feruloyl esterase is published by Phienluphon et al. and structures of AaFaeD-CD are available (8JH8, 8JH9) Crystal structure of HaloTag complexed with BTTA is available (8J1O) and will be published soon by Kim et aL. Structure of FphE, Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, fluorophosphonate JB101 bound is available (8SBQ) and will be published soon by Fellner et al.

Crystal structure of FphA, Staphylococcus aureus fluorophosphonate-binding serine hydrolases A, apo form is available (8S9J) as well as structure of SAL2, Staphylococcus aureus lipase 2 (geh, lip2) (8S9R) and will be published soon by Fellner et al. New structures of Hansschlegelia zhihuaiae SulE, a sulfonylurea herbicide de-esterification esterase ara available (8IVH, 8IW8) and will be published soon by Liu et al. Onset of Alzheimer disease in apolipoprotein E4 carriers is earlier in butyrylcholinesterase K variant carriers as published by Lane et al. Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles is published by Stojan et al. and structures of Torpedo californica AChE-MSF and AChE-MSF-BTA complexes are available (5EHX, 5EI5) A comprehensive review on the risk associated with organophosphorus nerve agents, current medical countermeasures and perspectives is published by Voros et al.

Amide formation of (hetero)aromatic esters and primary amines in buffer catalyzed by serine hydrolases: An Asp next to Ser of the catalytic triad of serine hydrolases is crucial for activity will be published soon by Zukic et al. and crystal structure of the lipase SpL from Sphingomonas sp. HXN-200 is available (8OIM) Deep sea bacterial PET plastic hydrolase MtCut with mutation S178C is available (8XHO) and will be published soon by Yang J Development of evolutionary algorithm-based protein redesign method has been published by Ozawa et al. and structure of GaHNL-12gen (artificial S-hydroxynitrile lyase) designed with this GAOptimizer is available (8J82) Treatment of organophosphorus poisoning with 6-Alkoxypyridin-3-ol Quinone Methide precursors is published by Clay et al. A paper by Bai et al. reviews acyl-Coenzyme A thioester hydrolase family in cancer

The web site for the the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 Due to security reasons the ESTHER database will change operating system in april. We hope it will be a smooth transition The structure of a Lactobacillus helveticus chlorogenic acid esterase and the dynamics of its insertion domain provide insights into substrate binding is published by Omori et al. and structures of wild type and K164A mutant are available (8SKM, 8SLJ)

The web site for the the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 Due to security reasons the ESTHER database will change operating system in april. We hope it will be a smooth transition A review on the role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology is published by Nagaoka et al. A Versatile thioesterase involved in dimerization during cinnamoyl lipid biosynthesis is published by Deng et al. A family was isolated Thioesterase-YsfF-HD Design of a gold nanoparticles site in an engineered lipase: an artificial metalloenzyme with enantioselective reductase-like activity is published by Garcia-Sanz et al.